Alan V. Smrcka
Biochemistry, Genetics and Molecular Biology · University of Michigan
Publications
248
Citations
12,137
Est. group size
~13
Recurring co-author estimate
Active years
41
Publishing since 1986
Typically publishes in teams of ~4 · 38% small-team papers (≤3 authors) · across 38 venues
- Activation of GPR97/ADGRG3 by its tethered agonist, but not by beclomethasone, induces neutrophil polarization and migration
Science Signaling · 2026
- G protein Gαq subunits engage targets in the nucleus involved in chromatin remodeling and gene expression
Journal of Biological Chemistry · 2026
- Mechanisms for enhancement of μ-opioid receptor-mediated antinociception in the central nervous system through gallein-dependent modulation of downstream G protein βγ subunit signaling
Molecular Pharmacology · 2026
- Biasing G protein βγ subunit downstream signaling enhances the analgesic effects of endogenous opioid receptor agonists during nitroglycerin-induced thermal hypersensitivity
Molecular Pharmacology · 2025
- Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening
Atherosclerosis · 2025
- GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gαo is disrupted by Gαo encephalopathy variants
Journal of Biological Chemistry · 2025
- Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy
Neurobiology of Disease · 2025
- GPR97/ADGRG3 is activated by its tethered peptide agonist and not by steroids to induce neutrophil polarization and migration
bioRxiv (Cold Spring Harbor Laboratory) · 2025
- Examining Promiscuity of a Gβγ Inhibitor, Gallein, for Enhancement of Antinociceptive Effects (Abstract ID: 163004)
Journal of Pharmacology and Experimental Therapeutics · 2025
- Gαq-SPRED1 Interaction: Unraveling a Novel Mechanism in GPCR Regulation of Ras Signaling (Abstract ID: 190690)
Journal of Pharmacology and Experimental Therapeutics · 2025
- Encephalopathy-Associated GNAO1 Mutant Effects on Rap1GAP1 Localization (Abstract ID: 171553)
Journal of Pharmacology and Experimental Therapeutics · 2025
- A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state
UNC Libraries · 2025
- A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state
Nature Communications · 2024
- Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling
Circulation Research · 2024
- Biasing Gβγ Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State
Molecular Pharmacology · 2024
- The FASEB Journal×24
- bioRxiv (Cold Spring Harbor Laboratory)×10
- Journal of Pharmacology and Experimental Therapeutics×8
- Molecular Pharmacology×7
- Journal of Biological Chemistry×6
- Naincy R. Chandan
Biochemistry, Genetics and Molecular Biology · University of Michigan
- Angeline M. Lyon
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Isaac J. Fisher
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Behirda Karaj
Biochemistry, Genetics and Molecular Biology · University of Michigan
- Chun-Liang Chen
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 25, 2026.
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