LabCompass

Isaac J. Fisher

Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

OpenAlex ORCID
Mid career · publishing since 2013Rising activity
Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and SignalingCellular transport and secretionMitochondrial Function and PathologyCell death mechanisms and regulation

Publications

38

Citations

161

Est. group size

~8

Recurring co-author estimate

Active years

14

Publishing since 2013

Research summary
AI-generated

Isaac J. Fisher studies how cells relay chemical signals inside them, focusing on a family of enzymes called phospholipase C (PLC), which help convert external signals (like hormones binding to receptors) into internal cellular responses. His work uses structural biology techniques such as cryo-electron microscopy (cryo-EM) to reveal how proteins like Gβγ, RhoA, and Ras-family GTPases physically interact with and activate different PLC enzymes. This research helps explain the molecular basis of cell signaling pathways relevant to processes like heart function and cellular growth control.

Phospholipase C structure and regulationG protein signaling (Gβγ, Gq)Small GTPase regulation (RhoA, Rap1A, Ras)Cryo-EM structural biologyCell signaling mechanisms

Publication output has grown over the past decade, with a modest and variable pace in earlier years followed by a marked increase in output since 2023.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 4.6/year recently
2017: 1 publication172018: 1 publication182019: 3 publications192020: 5 publications202021: 1 publication212022: 3 publications222023: 6 publications232024: 2 publications242025: 5 publications252026: 7 publications726
Recent publications
Publishes in
  • The FASEB Journal×7
  • Journal of Pharmacology and Experimental Therapeutics×6
  • bioRxiv (Cold Spring Harbor Laboratory)×5
  • Communications Biology×2
  • Journal of Biological Chemistry×2
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

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