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Chun-Liang Chen

Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

OpenAlex ORCID
Mid career · publishing since 2009Rising activity
Protein Kinase Regulation and GTPase SignalingEnzyme Structure and FunctionCellular transport and secretionCell Adhesion Molecules ResearchReceptor Mechanisms and Signaling

Publications

38

Citations

405

Est. group size

~7

Recurring co-author estimate

Active years

18

Publishing since 2009

Research summary
AI-generated

Chun-Liang Chen studies how cell-signaling proteins are structurally organized and activated inside cells, focusing on enzymes and molecular switches such as PI3-kinase, adenylyl cyclase, and RhoGEF proteins like P-Rex1 that respond to signals like G-proteins and lipid messengers (PIP3/IP4). This work uses structural and biophysical methods, sometimes with model cell membranes, to understand how these proteins turn on and off, which is relevant to processes like cell movement and certain neurological conditions. The research is basic molecular/structural biology rather than direct clinical application.

Protein structure and dynamicsG-protein signalingLipid-regulated enzyme activationRhoGEF/Rho GTPase signalingMembrane biophysics

Publication output was low and steady (1-2 per year) from 2017-2022, then increased sharply in 2023-2024 with a notable surge in preprints, journal articles, and peer review commentary.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 5.2/year recently
2017: 1 publication172018: 1 publication182019: 2 publications192020: 2 publications202021: 1 publication212022: 2 publications222023: 8 publications232024: 15 publications1524252026: 1 publication26
Recent publications
Publishes in
  • eLife×4
  • bioRxiv (Cold Spring Harbor Laboratory)×3
  • Nature Structural & Molecular Biology×2
  • Proceedings of the National Academy of Sciences×2
  • Journal of Biological Chemistry×2
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

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