Aki Inase

Biochemistry, Genetics and Molecular Biology · The Ohio State University

Mid career · publishing since 2003

DNA and Nucleic Acid Chemistry DNA Repair Mechanisms Cancer therapeutics and mechanisms Chronic Lymphocytic Leukemia Research Advanced biosensing and bioanalysis techniques

Publications

Citations

174

Est. group size

—

Recurring co-author estimate

Active years

Publishing since 2003

Research summary

AI-generated

Aki Inase's research focuses on understanding and overcoming drug resistance in leukemia treatment, particularly involving antibody-drug conjugates like gemtuzumab ozogamicin, a targeted cancer therapy that delivers toxic agents directly to leukemia cells. The work examines how combining this drug with other inhibitors (targeting cellular pathways like mTOR and GSK3) can improve its cancer-killing effects by disrupting the mechanisms leukemia cells use to resist treatment. This research sits at the intersection of cancer biology, pharmacology, and cell biology.

Antibody-drug conjugatesLeukemia treatment resistanceTargeted cancer therapyCell signaling and apoptosis pathwaysLysosomal function in cancer cells

Publications have been sparse and irregular over the last decade, with several gap years followed by a recent uptick in 2025-2026.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence

Publications per year over the last 10 years — averaging 0.8/year recently

Recent publications

Overcoming resistance to antibody-drug conjugates: mechanisms and emerging strategies
The Oncologist · 2026
GSK3 inhibitor enhances gemtuzumab ozogamicin‐induced apoptosis in primary human leukemia cells by overcoming multiple mechanisms of resistance
eJHaem · 2022
An mTORC1/2 dual inhibitor, AZD2014, acts as a lysosomal function activator and enhances gemtuzumab ozogamicin-induced apoptosis in primary human leukemia cells
International Journal of Hematology · 2019
An mTORC1/2 kinase inhibitor enhances the cytotoxicity of gemtuzumab ozogamicin by activation of lysosomal function
Leukemia Research · 2018

Publishes in

International Journal of Hematology×1
eJHaem×1
Leukemia Research×1
The Oncologist×1
Regular and Young Investigator Award Abstracts×1

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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 19, 2026.

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