Danzhou Yang
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
Publications
167
Citations
11,156
Est. group size
~7
Recurring co-author estimate
Active years
42
Publishing since 1985
Danzhou Yang's research focuses on the structure and function of G-quadruplexes and i-motifs, unusual folded shapes that DNA and RNA can form (instead of the typical double helix) in gene-regulatory regions such as gene promoters and telomeres (the protective ends of chromosomes). The lab studies how small molecules and proteins recognize these structures, aiming to design drugs that target cancer-related genes like MYC and KRAS by controlling gene activity through these DNA/RNA shapes. Work combines structural biology methods (like NMR), biophysical binding assays, and computational modeling to characterize these interactions.
Publication output has fluctuated over the past decade, peaking in 2019 and settling to a lower, fairly steady rate of roughly 5-10 papers per year in recent years.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Functional analysis of AtTX11/12 TIR-domain proteins identifies key residues for basal and temperature-insensitive growth inhibition
Biochemical and Biophysical Research Communications · 2025
- Abstract 4257: Discovery of small molecules to target DDX5 unfolding of MYC promoter G-quadruplex for MYC inhibition
Cancer Research · 2025
- Subnanomolar Sensitive Stable Isotopic Determination in CO<sub>2</sub> by Tunable Infrared Laser Absorption Spectroscopy
Analytical Chemistry · 2022
- Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes
ACS Chemical Biology · 2020
- Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity
Molecules · 2020
- Combining Alchemical Transformation with a Physical Pathway to Accelerate Absolute Binding Free Energy Calculations of Charged Ligands to Enclosed Binding Sites
Journal of Chemical Theory and Computation · 2020
- G-Quadruplex DNA and RNA
Methods in molecular biology · 2019
- Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition
Nucleic Acids Research · 2019
- G-Quadruplex Nucleic Acids
Methods in molecular biology · 2019
- Pulsed Terahertz Radiation for Sensitive Quantification of Carbonate Minerals
ACS Omega · 2019
- High-Throughput Screening of G-Quadruplex Ligands by FRET Assay
Methods in molecular biology · 2019
- Ligand Selectivity in the Recognition of Protoberberine Alkaloids by Hybrid-2 Human Telomeric G-Quadruplex: Binding Free Energy Calculation, Fluorescence Binding, and NMR Experiments
Molecules · 2019
- Abstract 2752: Recognition of the hybrid-1 human telomeric G-quadruplex by a platinum(II)-based compound
Cancer Research · 2019
- Abstract 2752: Recognition of the hybrid-1 human telomeric G-quadruplex by a platinum(II)-based compound
Cancer Chemistry · 2019
- Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
Nature Communications · 2018
- Cancer Research×30
- Journal of the American Chemical Society×9
- Methods in molecular biology×6
- Nucleic Acids Research×4
- Molecules×4
- Jonathan Dickerhoff
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Clement Lin
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Buket Onel
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Besik Kankia
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Kai‐Bo Wang
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
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