Publications
78
Citations
2,006
Est. group size
~15
Recurring co-author estimate
Active years
28
Publishing since 1999
Svetlana B. Tikunova studies the molecular basis of muscle contraction, focusing on how calcium-binding proteins like troponin C and calmodulin regulate heart and skeletal muscle function. Her work combines structural biology, computational screening, and mutation studies to identify small molecules that could adjust calcium sensitivity in muscle, with relevance to heart failure and cardiomyopathy. Prospective students would likely engage with biochemistry, biophysics, and drug-discovery approaches applied to cardiac and skeletal muscle proteins.
Publication output has been variable but generally steady over the last decade, with recurring active years (e.g., 2018, 2022, 2023) interspersed with lower-output years (2021, 2024), and no clear long-term upward or downward trend.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- BPS2026 – Troponin enhanceropathies: A novel role for the troponin genes
Biophysical Journal · 2026
- Molecular interactions of the NaV1.5 C-terminal domain: CaM sequestered the IQ motif from the CTD
Journal of Biological Chemistry · 2025
- Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure–Activity Relationship
Journal of Chemical Information and Modeling · 2023
- Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C
International Journal of Molecular Sciences · 2023
- Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship
bioRxiv (Cold Spring Harbor Laboratory) · 2023
- Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction
Frontiers in Physiology · 2022
- Troponin C mutations alter twitch kinetics and force-frequency relationship of fast and slow twitch skeletal muscle
Biophysical Journal · 2022
- RPI‐194 is a Novel Troponin Activator that Increases the Calcium Sensitivity of Striated Muscle Contraction
The FASEB Journal · 2022
- Targeting systolic heart failure: A newly developed troponin activator RPI-194 increases striated muscle contraction by acting as a calcium sensitizer
Journal of Molecular and Cellular Cardiology · 2022
- Discovery of Novel Small-Molecule Calcium Sensitizers for Cardiac Troponin C: A Combined Virtual and Experimental Screening Approach
Journal of Chemical Information and Modeling · 2020
- Calmodulin–Calcineurin Interaction beyond the Calmodulin-Binding Region Contributes to Calcineurin Activation
Biochemistry · 2019
- Virtual Screening Finds Troponin Calcium Sensitizers and Umbrella Sampling Simulations Elucidate Differences in Troponin C Isoform and Mutant Hydrophobic Patch Exposure
Biophysical Journal · 2019
- Molecular basis of calmodulin-dependent calcineurin activation
bioRxiv (Cold Spring Harbor Laboratory) · 2019
- Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders
Journal of Molecular and Cellular Cardiology · 2018
- 3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP
The Journal of General Physiology · 2018
- Biophysical Journal×13
- Journal of Chemical Information and Modeling×3
- Frontiers in Physiology×2
- Journal of Molecular and Cellular Cardiology×2
- International Journal of Molecular Sciences×2
- Elizabeth A. Brundage
Medicine · The Ohio State University
- Heather R. Manring
Medicine · The Ohio State University
- Jason Cowan
Medicine · The Ohio State University
- Brandon J. Biesiadecki
Medicine · The Ohio State University
- Ray E. Hershberger
Medicine · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
Claim or correct this profile