LabCompass

Heather R. Manring

Medicine · The Ohio State University

OpenAlex ORCID
Mid career · publishing since 2012Rising activity
Cardiomyopathy and Myosin StudiesCardiovascular Effects of ExerciseCardiac electrophysiology and arrhythmiasCalpain Protease Function and RegulationMuscle Physiology and Disorders

Publications

39

Citations

381

Est. group size

~6

Recurring co-author estimate

Active years

14

Publishing since 2012

Research summary
AI-generated

Heather R. Manring's research focuses on the molecular basis of arrhythmogenic cardiomyopathy, a heart condition affecting the electrical rhythm and structural integrity of heart muscle cells. Much of the work centers on desmoplakin, a protein important for holding heart cells together, and how disease-linked mutations make it more vulnerable to being broken down by an enzyme called calpain; the lab has also explored engineered 'molecular band-aid' strategies to protect desmoplakin from this degradation. Related work examines other heart structural and signaling proteins, such as obscurin and MG53, in the context of heart failure and muscular dystrophy.

Arrhythmogenic cardiomyopathy mechanismsDesmoplakin structure and calpain-mediated degradationCardiac intercalated disc biologyProtein engineering therapeutics ('molecular band-aid')Muscle and heart structural proteins (obscurin, MG53)

Publication output peaked around 2018-2019, declined through 2021-2023, and has shown a modest resurgence in 2024-2025, suggesting an overall slowing but not inactive pace over the last decade.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 2.6/year recently
2017: 4 publications172018: 6 publications6182019: 6 publications6192020: 4 publications202021: 2 publications212022: 2 publications222023: 2 publications232024: 5 publications242025: 4 publications2526
Recent publications
Publishes in
  • Biophysical Journal×11
  • Cancer Research×3
  • Radiotherapy and Oncology×3
  • Biophysical Reviews×2
  • Scientific Reports×2
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 19, 2026.

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