Publications
123
Citations
2,833
Est. group size
~4
Recurring co-author estimate
Active years
29
Publishing since 1998
This researcher studies the molecular machinery that controls how heart and skeletal muscle contract, focusing on proteins like troponin and tropomyosin that regulate muscle force and relaxation. Much of the work examines how mutations or chemical modifications (such as phosphorylation) of these proteins affect muscle function and contribute to diseases like dilated cardiomyopathy. The research combines biochemistry, biophysics, and physiology to link molecular changes to whole-muscle and heart performance.
Publication output was fairly steady at 6-9 papers per year from 2017 to 2022, then declined noticeably from 2023 onward.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- TNNT2 mutations in the tropomyosin-binding segment of TNT1 engender dilated cardiomyopathy in Drosophila
Biophysical Journal · 2024
- Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts
The Journal of General Physiology · 2023
- Thin filament regulation of striated muscle power output: implications for targets to improve failing human hearts
Biophysical Journal · 2023
- Molecular regulation of stretch activation
American Journal of Physiology-Cell Physiology · 2022
- Cardiac Troponin I N-Terminal Pseudo-Phosphorylation Regulates Power Output and Stretch Activation
Biophysical Journal · 2021
- <i>TNNT2</i> mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction
Proceedings of the National Academy of Sciences · 2020
- Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity
Journal of Molecular and Cellular Cardiology · 2020
- Mutations in the TnT1 Tropomyosin-Binding Element of Troponin-T Alter Its Inhibitory Properties and Stimulate Myocardial Dysfunction
Biophysical Journal · 2020
- Troponin I modulation of cardiac performance: Plasticity in the survival switch
Archives of Biochemistry and Biophysics · 2019
- Rats genetically selected for low and high aerobic capacity exhibit altered soleus muscle myofilament functions
American Journal of Physiology-Cell Physiology · 2019
- Troponin I Tyrosine Phosphorylation: Novel Regulator of Cardiac Function
Biophysical Journal · 2019
- Current and Future Directions of Myofilament Regulation
Archives of Biochemistry and Biophysics · 2019
- Abstract 109: Site-specific Acetylation of Cardiac Troponin I Regulates Myofilament Relaxation and Calcium Sensitivity
Circulation Research · 2019
- Abstract 900: Troponin I Tyrosine 26 Phosphorylation Accelerates i <i>n vivo</i> Myocardial Relaxation
Circulation Research · 2019
- Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis
Journal of Biological Chemistry · 2018
- Biophysical Journal×14
- Circulation Research×10
- Archives of Biochemistry and Biophysics×4
- Scientific Reports×3
- Circulation×3
- Heather R. Manring
Medicine · The Ohio State University
- Shane D. Walton
Medicine · The Ohio State University
- Jonathan P. Davis
Medicine · The Ohio State University
- Paul M.L. Janssen
Medicine · The Ohio State University
- Ray E. Hershberger
Medicine · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
Claim or correct this profile