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Sebastian Kenny

Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

OpenAlex ORCID
Early career · publishing since 2020Rising activity
Ubiquitin and proteasome pathwaysEnzyme Structure and FunctionProtein Degradation and InhibitorsProtein Structure and DynamicsRNA and protein synthesis mechanisms

Publications

14

Citations

232

Est. group size

~1

Recurring co-author estimate

Active years

7

Publishing since 2020

Research summary
AI-generated

Sebastian Kenny's research focuses on proteins involved in cellular regulation, including how ubiquitin (a small protein tag that marks other proteins for degradation) and related enzymes control protein breakdown, and more recently on computationally designing new proteins that can bind to specific targets such as disordered proteins, kinases, or immune cells. This work spans structural biology of enzyme complexes and cutting-edge protein design methods, including applications to engineering CAR T-cells (immune cells modified to fight disease) and targeted protein degradation technologies called bioPROTACs.

Ubiquitin and protein degradation pathwaysDeubiquitinating enzymes and their structuresComputational and de novo protein designBinding proteins for intrinsically disordered regionsProtein engineering for immunotherapy (CAR T-cells) and targeted degradation

Publication output was minimal or absent in the earlier part of the decade but has increased notably since 2024, suggesting a recent growth phase.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 1.8/year recently
1718192020: 3 publications202021: 2 publications2122232024: 3 publications242025: 4 publications4252026: 2 publications26
Recent publications
Publishes in
  • bioRxiv (Cold Spring Harbor Laboratory)×3
  • Nature Communications×2
  • Biochemistry×2
  • Science×1
  • Nature×1
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  • Darci J. Trader

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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

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