LabCompass

Darci J. Trader

Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

OpenAlex ORCID
Mid career · publishing since 2006Rising activity
Ubiquitin and proteasome pathwaysProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisEndoplasmic Reticulum Stress and DiseaseChemical Synthesis and Analysis

Publications

76

Citations

1,148

Est. group size

~5

Recurring co-author estimate

Active years

21

Publishing since 2006

Research summary
AI-generated

Darci J. Trader's lab studies the proteasome, the cell's protein-disposal machinery, focusing on how to activate or inhibit its activity for therapeutic purposes. Their work includes designing small molecules and 'degrader' compounds that either boost proteasome function (potentially protecting cells from stress-related damage) or direct it to destroy specific disease-related proteins, such as through novel targeted protein degradation strategies. This research spans chemical synthesis, structural biology, and cell biology techniques including NMR and live imaging.

Proteasome biology and regulationTargeted protein degradation (degraders, PROTACs, ByeTACs)Immunoproteasome-selective drug designSmall-molecule proteasome activatorsChemical biology methods (NMR, synthesis, imaging)

Publication output has grown substantially in recent years, rising from a handful of papers per year in the late 2010s to a peak of over a dozen annually in 2024-2025.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 7.2/year recently
2017: 1 publication172018: 6 publications182019: 10 publications192020: 8 publications202021: 5 publications212022: 3 publications222023: 4 publications232024: 12 publications242025: 13 publications13252026: 4 publications26
Recent publications
Publishes in
  • ChemBioChem×9
  • Journal of Medicinal Chemistry×6
  • ChemRxiv×6
  • Current Protocols×4
  • Journal of the American Chemical Society×3
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

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