Publications
141
Citations
5,202
Est. group size
—
Recurring co-author estimate
Active years
56
Publishing since 1970
This publication record appears to blend two distinct areas: laboratory research on proteolytic enzymes (particularly the ADAMTS family of proteases) and their roles in connective tissue, cardiovascular, and joint diseases, alongside separate work on emergency medicine practice, ethics, and academic leadership. The lab-based work focuses on how enzymes cut and modify extracellular matrix proteins, contributing to conditions like osteoarthritis, aortic aneurysms, and heart failure, using proteomics techniques to map these cleavage events (sometimes called 'degradomics'). Note that the topic scores provided are all listed as 0.00, so thematic weighting could not be reliably determined from that data alone.
Publication output over the last decade has been relatively steady with some fluctuation, rising from about 3-4 papers per year (2017-2020) to a peak of 7 in 2021, dipping to 2 in 2023, and returning to around 5 per year in 2024-2025.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Characterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5
Journal of Biological Chemistry · 2025
- DICED (Database of Identified Cleavage Sites Endemic to Diseases States): A Searchable Web Interface for Terminomics/Degradomics
PROTEOMICS · 2025
- Focal Adhesion Kinase Drives Rho/ROCK and mTOR Signaling to Protect and Augment Aortic Dissections
JACC Basic to Translational Science · 2025
- Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes
Life Science Alliance · 2025
- BS10 Characterising the degradome of the metalloprotease ADAMTS8: implications for pulmonary arterial hypertension
2025
- Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease
Matrix Biology · 2024
- Emergency Physicians’ Ethical Issues with Hospital Business Models
Journal of Emergency Medicine · 2024
- Basic Science Aspects of the Pathogenesis of Infective Endocarditis
2024
- Leadership Development and Its Association With Retention of Surgical Versus Nonsurgical Faculty at a Large Academic Health Center
Journal of Surgical Research · 2024
- Integrated forward and reverse degradomics uncovers the proteolytic landscape of aortic aneurysms and the roles of MMP9 and mast cell chymase
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate
Molecular & Cellular Proteomics · 2023
- Observations about declining fertility in a feline breeding colony
Theriogenology · 2023
- Proteolysis: a key post-translational modification regulating proteoglycans
American Journal of Physiology-Cell Physiology · 2022
- ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Communications Biology · 2022
- Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry
Cell chemical biology · 2022
- bioRxiv (Cold Spring Harbor Laboratory)×3
- Journal of the American College of Emergency Physicians Open×2
- Journal of Biological Chemistry×2
- Journal of Emergency Medicine×2
- Academic Emergency Medicine×2
- Nicholas Kman
Medicine · The Ohio State University
- Alyssa Tyransky
Medicine · The Ohio State University
- Alex N. Isaacs
Medicine · Purdue University West Lafayette
- Allison Macerollo
Medicine · The Ohio State University
- Aloysius J. Humbert
Medicine · Indiana University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
Claim or correct this profile