Cynthia V. Stauffacher
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
Publications
141
Citations
4,640
Est. group size
~2
Recurring co-author estimate
Active years
57
Publishing since 1970
Cynthia V. Stauffacher's research uses structural biology and biochemistry to study enzymes and proteins involved in metabolism and cellular signaling, with a particular focus on HMG-CoA reductase, an enzyme involved in cholesterol/lipid-related biosynthesis pathways. Her work combines X-ray crystallography, computational simulations, and chemical synthesis of specialized probe molecules to understand how these enzymes work at the molecular level and how mutations affect their function, with applications ranging from bacterial enzymes to human disease-related proteins.
Publication output has gradually declined over the last decade, from a peak of about 5-7 papers per year in 2017-2018 to roughly 2-3 papers per year in recent years.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Synthesis of Caged HMG-CoA Reductase Substrates for Elucidation of Cellular Pathways
ChemRxiv · 2024
- Synthesis of Caged HMG-CoA Reductase Substrates for the Elucidation of Cellular Pathways
The Journal of Organic Chemistry · 2024
- Heterogeneity in Lowe Syndrome: Mutations Affecting the Phosphatase Domain of OCRL1 Differ in Impact on Enzymatic Activity and Severity of Cellular Phenotypes
Biomolecules · 2023
- Computational Study of Base-Catalyzed Thiohemiacetal Decomposition in <i>Pseudomonas mevalonii</i> HMG-CoA Reductase
The Journal of Physical Chemistry B · 2023
- Essential amino acids in the Plant-Conserved and Class-Specific Regions of cellulose synthases
PLANT PHYSIOLOGY · 2022
- Utilizing a pH-dependent reaction triggering method to elucidate the mechanism of bacterial HMG-CoA reductase using time-resolved crystallography
Biophysical Journal · 2022
- Microsecond timescale MD simulations at the transition state of <i>Pm</i> HMGR predict remote allosteric residues
Chemical Science · 2021
- Investigating Bacterial Malonyl-COA:Acyl Transferase as a Potential Secondary Target of 3-Hydroxy-3-Methyl-Glutaryl-COA Reductase Inhibitors
Biophysical Journal · 2021
- Microsecond Timescale Simulations at the Transition State of PmHMGR Predict Remote Allosteric Residues
ChemRxiv · 2019
- Microsecond Timescale Simulations at the Transition State of PmHMGR Predict Remote Allosteric Residues
ChemRxiv · 2019
- pHP-Tethered <i>N</i>-Acyl Carbamate: A Photocage for Nicotinamide
Organic Letters · 2018
- Conformational Dynamics in the Binding-Protein-Independent Mutant of the <i>Escherichia coli</i> Maltose Transporter, MalG511, and Its Interaction with Maltose Binding Protein
Biochemistry · 2018
- Using pH Changes to Obtain Time-Resolved Crystallographic Structures of HMG-CoA Reductase
Biophysical Journal · 2018
- Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. <i>Nature</i>. 1994. 368: 711-718.
PubMed · 2018
- MDDEF in complex with MVAPP, ADP, sulfate and cobalt
2018
- Biophysical Journal×10
- ChemRxiv×5
- PLANT PHYSIOLOGY×2
- Nature Communications×1
- Nucleic Acids Research×1
- Chandra J. Critchelow
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- C.N. Steussy
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Vatsal Purohit
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Tim Schmidt
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Itay Maoz
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
Claim or correct this profile