LabCompass

Chandra J. Critchelow

Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

OpenAlex
Mid career · publishing since 2012
Plant biochemistry and biosynthesisMicrobial Metabolism and ApplicationsComputational Drug Discovery MethodsEnzyme Structure and FunctionCancer therapeutics and mechanisms

Publications

12

Citations

23

Est. group size

—

Recurring co-author estimate

Active years

13

Publishing since 2012

Research summary
AI-generated

Chandra J. Critchelow's work focuses on studying the enzyme HMG-CoA reductase from bacteria (Pseudomonas mevalonii) using time-resolved crystallography, a technique that captures snapshots of molecular structures as chemical reactions happen. The research aims to understand how this enzyme transfers hydride ions and how pH changes can be used to trigger and observe these reactions in fine structural detail. This work relates to broader questions in biochemistry about enzyme mechanisms and structural biology methods.

Enzyme structure and mechanismTime-resolved crystallographypH-triggered chemical reactionsHMG-CoA reductase biochemistryStructural biology methods

Publication output has been low and sporadic over the last decade, with only a handful of papers appearing between 2019 and 2024 and no clear growth trend.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 0.2/year recently
17182019: 1 publication192020: 2 publications2202021: 1 publication2122232024: 1 publication242526
Recent publications
Publishes in
  • Biophysical Journal×4
  • bioRxiv (Cold Spring Harbor Laboratory)×1
Similar researchers
By research-topic overlap
  • C.N. Steussy

    Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

  • Vatsal Purohit

    Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

  • Tim Schmidt

    Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

  • Cynthia V. Stauffacher

    Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

  • Benoît Boachon

    Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

Claim or correct this profile