Nicole D. Schartz
Neuroscience · Purdue University West Lafayette
Publications
28
Citations
733
Est. group size
—
Recurring co-author estimate
Active years
14
Publishing since 2013
Nicole D. Schartz studies how the brain's immune system contributes to neurological disease, focusing on the complement system (a set of immune proteins) and its role in Alzheimer's disease and epilepsy. Much of this work examines how blocking specific complement signaling molecules, such as C5aR1 and C3, affects brain inflammation, memory loss, and the elimination of synapses (connections between brain cells) in mouse models. The research aims to understand whether targeting these immune pathways could reduce cognitive decline in neurodegenerative and seizure-related conditions.
Publication output was low and intermittent from 2017-2021, rose to a peak in 2022, and has continued at a moderate, steady pace through 2023-2024.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Temporal profiling of hippocampal astrocyte reactivity reveals persistent GFAP cleavage and complement C3 association after status epilepticus
Research Square · 2026
- C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model
Nature Communications · 2024
- C5aR1 signaling promotes region‐ and age‐dependent synaptic pruning in models of Alzheimer's disease
Alzheimer s & Dementia · 2024
- Acute depletion of complement <scp>C3</scp> with cobra venom factor attenuates memory deficits induced by status epilepticus
Epilepsia Open · 2024
- Mice deficient in complement C3 are protected against recognition memory deficits and astrogliosis induced by status epilepticus
Frontiers in Molecular Neuroscience · 2023
- C5aR1 antagonism suppresses inflammatory glial gene expression and alters cellular signaling in an aggressive Alzheimer’s model
bioRxiv (Cold Spring Harbor Laboratory) · 2023
- C5aR1 signaling promotes region and age dependent synaptic pruning in models of Alzheimer’s Disease
bioRxiv (Cold Spring Harbor Laboratory) · 2023
- 67 Strategic targeting of complement to regulate neuroinflammation and synapse pruning in Alzheimer’s disease
Immunobiology · 2023
- Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
Journal of Neuroinflammation · 2022
- C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease
Acta Neuropathologica Communications · 2022
- Modulation of C5a-C5aR1 signaling alters the dynamics of AD progression
bioRxiv (Cold Spring Harbor Laboratory) · 2022
- C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease
bioRxiv (Cold Spring Harbor Laboratory) · 2022
- Treatment with C5aR1 antagonist attenuates short‐term hippocampal memory decline and prevents DAM signature in Arctic mice.
Alzheimer s & Dementia · 2022
- Additional file 5 of C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease
Figshare · 2022
- Additional file 4 of C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease
Figshare · 2022
- bioRxiv (Cold Spring Harbor Laboratory)×4
- Journal of Neuroinflammation×2
- Alzheimer s & Dementia×2
- Figshare×2
- Neurobiology of Disease×1
- Jie Gao
Neuroscience · The Ohio State University
- Holly M. Brothers
Neuroscience · The Ohio State University
- Andy P. Tsai
Neuroscience · Indiana University
- Luke C. Dabin
Neuroscience · Indiana University
- Season K. Wyatt‐Johnson
Neuroscience · Indiana University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
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