Naoaki Fujii
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
Publications
67
Citations
2,470
Est. group size
~4
Recurring co-author estimate
Active years
39
Publishing since 1988
Naoaki Fujii's research focuses on discovering small molecules that block specific protein-protein interactions involved in DNA damage repair and tolerance, such as those involving PCNA, REV1, and REV7 proteins. This work has applications in cancer biology and also extends to developing chemical countermeasures against cyanide poisoning using platinum-based compounds. The research combines chemical biology, structural biology, and toxicology approaches to design and test candidate therapeutic molecules.
Publication output has been low and irregular over the last decade, with small clusters of activity (1-2 papers) in most years and several years with no recorded output.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- A pilot study in the swine model of lethal cyanide intoxication indicates efficacy of a platinum-methionine complex countermeasure
Scientific Reports · 2026
- Investigating the replacement of carboxylates with carboxamides to modulate the safety and efficacy of platinum(II) thioether cyanide scavengers
Toxicological Sciences · 2023
- A phenotypic screen with <i>Trypanosoma brucei</i> for discovering small molecules that target the SLiM‐binding pocket of proliferating cell nuclear antigen orthologs
Chemical Biology & Drug Design · 2023
- Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures
Chemical Research in Toxicology · 2022
- Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance
Bioorganic & Medicinal Chemistry · 2018
- Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2–Ubiquitin Interaction
Journal of Molecular Biology · 2018
- Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6
Gastroenterology · 2017
- Potential Strategies to Target Protein–Protein Interactions in the DNA Damage Response and Repair Pathways
Journal of Medicinal Chemistry · 2017
- Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction
Bioorganic & Medicinal Chemistry · 2016
- A clickable psoralen to directly quantify DNA interstrand crosslinking and repair
Bioorganic & Medicinal Chemistry · 2016
- Bioorganic & Medicinal Chemistry×3
- Gastroenterology×1
- European Journal of Medicinal Chemistry×1
- Chemical Research in Toxicology×1
- Toxicological Sciences×1
- Renee A. Bouley
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Jun Wan
Biochemistry, Genetics and Molecular Biology · Indiana University
- Junran Zhang
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Mohamed Elmahdy
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Alexander J.R. Bishop
Biochemistry, Genetics and Molecular Biology · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
Claim or correct this profile