Mark Cushman

Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

Established · publishing since 1978

Biochemical and Molecular Research Enzyme Structure and Function HIV/AIDS drug development and treatment Folate and B Vitamins Research Carbohydrate Chemistry and Synthesis

Publications

138

Citations

4,220

Est. group size

—

Recurring co-author estimate

Active years

Publishing since 1978

Research summary

AI-generated

Mark Cushman's research focuses on designing and synthesizing small-molecule drug candidates, including enzyme inhibitors targeting topoisomerase I (relevant to cancer and to reactivating a silenced gene linked to Angelman syndrome), non-nucleoside reverse transcriptase inhibitors for HIV treatment, and antibacterial ketolide compounds. This work combines organic chemistry (drug synthesis) with structure-activity relationship studies to understand how chemical structure influences biological effectiveness.

Medicinal chemistry and drug designTopoisomerase I inhibitorsHIV/antiviral drug developmentAntibacterial compound synthesisStructure-activity relationship studies

Publication output was modest and has slowed substantially, with only a few papers in 2017-2018 and just one recent publication in 2024, none in most other years of the past decade.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence

Publications per year over the last 10 years — averaging 0.2/year recently

Recent publications

Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome
Molecular Autism · 2018
University of Minnesota University of Michigan DRUG ANNOTATIONS EDITORS PERSPECTIVE EDITOR EDITOR EMERITUS EDITORIAL ADVISORY BOARD
2018
Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides
Bioorganic & Medicinal Chemistry Letters · 2017
University of Michigan DRUG ANNOTATIONS EDITORS PERSPECTIVES EDITOR EDITOR EMERITUS MANAGING EDITOR EDITORIAL ADVISORY BOARD
2017
Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy
Bioorganic & Medicinal Chemistry · 2016
ChemInform Abstract: One‐Step Synthetic Access to Isosteric and Potent Anticancer Nitrogen Heterocycles with the Benzo[c]phenanthridine Scaffold.
ChemInform · 2016

Publishes in

Molecular Autism×1
Bioorganic & Medicinal Chemistry Letters×1
Bioorganic & Medicinal Chemistry×1
ChemInform×1
Cancer Research×1

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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

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