Marcos Sotomayor
Biochemistry, Genetics and Molecular Biology · The Ohio State University
Publications
157
Citations
7,176
Est. group size
~10
Recurring co-author estimate
Active years
35
Publishing since 1992
Marcos Sotomayor studies the molecular machinery behind hearing and mechanical sensing in cells, using structural biology and computer simulations to understand how proteins like cadherins, ion channels, and lipid-handling proteins work together to convert physical force into biological signals. Much of the work focuses on inner-ear proteins involved in hearing and touch-like sensing, as well as related membrane proteins in other biological contexts. The lab combines experimental structures with computational modeling (including molecular dynamics simulations and AlphaFold-based predictions) to explain how these proteins function mechanically at the atomic level.
Publication output has declined somewhat from a peak around 2017-2019 to a lower but relatively steady pace of roughly 7-11 papers per year in recent years.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- BPS2026 – Molecular determinants of lipid scrambling from coarse-grained simulations
Biophysical Journal · 2026
- In silico analyses of molecular force sensors for mechanical characterization of biological systems
Biophysical Journal · 2025
- TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells
bioRxiv (Cold Spring Harbor Laboratory) · 2025
- Groove architecture controls lipid scrambling in simulations of protein and model systems
bioRxiv (Cold Spring Harbor Laboratory) · 2025
- Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade
Cell Reports · 2025
- CELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain
Structure · 2024
- <i>In-Silico</i> Analyses of Molecular Force Sensors for Mechanical Characterization of Biological Systems
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- Structure of a non-mammalian cadherin heterodimer suggests a general binding mechanism essential for hair-cell mechanotransduction
Biophysical Journal · 2023
- A curated AlphaFold 2/AlphaFill cadherinosome
Biophysical Journal · 2023
- Towards an atomistic model of the vertebrate inner-ear transduction apparatus
Biophysical Journal · 2023
- A hydrophilic microenvironment in the substrate-translocating groove of the YidC membrane insertase is essential for enzyme function
Journal of Biological Chemistry · 2022
- Collective mechanical responses of cadherin-based adhesive junctions as predicted by simulations
Biophysical Journal · 2022
- Elastic versus brittle mechanical responses predicted for dimeric cadherin complexes
Biophysical Journal · 2022
- Molecular mechanisms underlying CIB function in inner-ear mechanotransduction
Biophysical Journal · 2022
- Elucidating the structural determinant of CELSR1 function involved in planar cell polarity
Biophysical Journal · 2022
- Biophysical Journal×29
- bioRxiv (Cold Spring Harbor Laboratory)×16
- Structure×5
- eLife×4
- Neuron×3
- Elakkiya Tamilselvan
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Michelle R. Emond
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- James D. Jontes
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Jae-Uk Chung
Biochemistry, Genetics and Molecular Biology · Indiana University
- James A. Marrs
Biochemistry, Genetics and Molecular Biology · Indiana University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
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