Mamuka Kvaratskhelia
Immunology and Microbiology · The Ohio State University
Publications
159
Citations
6,101
Est. group size
~2
Recurring co-author estimate
Active years
30
Publishing since 1997
This researcher studies how HIV-1 replicates inside human cells, focusing on the structure and function of viral proteins like integrase and capsid, and how they interact with host cell components such as CPSF6, MX2, and nuclear pore proteins. A major goal of this work is to understand how the virus becomes resistant to antiviral drugs (such as integrase inhibitors and capsid-targeting drugs like lenacapavir) and to help design better treatments. Students in this area would likely work on structural biology, biochemistry, and virology techniques applied to HIV drug resistance.
Publication output has remained fairly steady over the last decade, with modest year-to-year fluctuations (roughly 5-10 papers annually) and a recent uptick in 2024-2025.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Retrointegration2023—Papers from the 7th International Conference on Retroviral Integration
Viruses · 2025
- Erratum for Dinh et al., “The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir”
mBio · 2025
- Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins
mBio · 2025
- Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding
Nature Communications · 2025
- Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir
mBio · 2025
- Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions
2024
- The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- Structural and Mechanistic Bases for Resistance of the M66I Capsid Variant to Lenacapavir
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase–RNA interactions
ACS Medicinal Chemistry Letters · 2024
- The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir
mBio · 2024
- Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions
PLoS Pathogens · 2024
- CPSF6 assembly dynamics and binding avidity on HIV-1 capsid are regulated by interactions between prion-like low complexity regions
Biophysical Journal · 2023
- bioRxiv (Cold Spring Harbor Laboratory)×13
- mBio×7
- Journal of Virology×4
- eLife×3
- Journal of Biological Chemistry×3
- Ekaterina Knyazhanskaya
Immunology and Microbiology · Indiana University
- Ross C. Larue
Immunology and Microbiology · The Ohio State University
- Kristine E. Yoder
Immunology and Microbiology · The Ohio State University
- Ajay K. Ghosh
Immunology and Microbiology · Purdue University West Lafayette
- Amit Sharma
Immunology and Microbiology · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
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