J.J.G. Tesmer

This researcher studies the molecular structures and mechanisms of proteins involved in cell signaling, especially G protein-coupled receptor kinases (GRKs) that regulate how cells respond to hormones and neurotransmitters. Much of the work combines structural biology techniques like X-ray crystallography and cryo-EM with drug design to develop selective inhibitors of these kinases, with relevance to conditions such as heart failure and thrombosis (blood clotting). The lab also investigates related enzymes and receptor systems, including lipid metabolism proteins and receptors involved in developmental signaling pathways.

Publication output has fluctuated over the past decade, dipping in the early 2020s before rising again in 2023-2024, with recent years averaging about 14 papers annually.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026