Hazem E. Ghoneim

Hazem E. Ghoneim studies how immune cells called T cells develop, remember past infections, and sometimes become dysfunctional or 'exhausted' during chronic infections and cancer. A major focus is on epigenetics—chemical modifications to DNA (such as methylation) that control which genes T cells turn on or off—and how these programs affect T cell memory, exhaustion, and responses to cancer immunotherapies like checkpoint blockade. The lab also explores related topics such as T cell metabolism, regulatory T cells in metabolic disease, and immune cell function in diabetes and viral infection.

Publication output has grown substantially over the past decade, rising from a few papers per year around 2017-2019 to a notable spike in 2025, indicating an increasingly active and productive research program.

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