Frederick Nguele Meke
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
Publications
43
Citations
202
Est. group size
~10
Recurring co-author estimate
Active years
7
Publishing since 2020
Frederick Nguele Meke's research focuses on how certain enzymes called phosphatases (proteins that remove phosphate groups from other proteins) control cancer-related signaling pathways, particularly in blood cancers like leukemia and lymphoma. Recent work examines proteins such as PRL2 and SHP2, studying how blocking their activity affects tumor growth and other cellular processes like protein breakdown (autophagy). The lab also uses advanced imaging and mass spectrometry techniques to study protein forms within tissue samples.
Publication output was minimal or absent for most of the past decade but increased sharply starting in 2022, with a pronounced spike in 2024, suggesting a recent period of growing research activity.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers
Journal of Clinical Investigation · 2024
- Nano-DESI Mass Spectrometry Imaging of Proteoforms in Biological Tissues with High Spatial Resolution
Analytical Chemistry · 2023
- PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
JCI Insight · 2023
- Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis
Proceedings of the National Academy of Sciences · 2020
- Cancer Research×2
- Analytical Chemistry×1
- Proceedings of the National Academy of Sciences×1
- Blood×1
- Autophagy×1
- Qinglin Li
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Jinmin Miao
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Jinan Ayub
Biochemistry, Genetics and Molecular Biology · Indiana University
- Darien E. Reed
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Cho-Hao Lin
Biochemistry, Genetics and Molecular Biology · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
Claim or correct this profile