LabCompass

Emily C. Dykhuizen

Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

OpenAlex ORCID
Mid career · publishing since 2003Rising activity
Chromatin Remodeling and CancerProtein Degradation and InhibitorsGenomics and Chromatin DynamicsEpigenetics and DNA MethylationCancer-related gene regulation

Publications

85

Citations

2,525

Est. group size

~18

Recurring co-author estimate

Active years

24

Publishing since 2003

Research summary
AI-generated

Emily C. Dykhuizen's research focuses on chromatin remodeling complexes—large protein machines that control which genes are turned on or off by repackaging DNA—particularly the SWI/SNF (BAF) family and their roles in cancer. Her lab studies how mutations in subunits like PBRM1, ARID1A, and BRD7 affect protein function, gene regulation, and immune signaling, and develops small-molecule chemical probes and inhibitors that target specific 'reader' domains (such as bromodomains) to block these proteins' activity, especially in prostate cancer and other tumor types. This work combines structural biology, biochemistry, and drug discovery approaches to understand and potentially treat cancers driven by chromatin regulator mutations.

Chromatin remodeling (SWI/SNF/BAF complexes)Cancer-associated protein mutations (PBRM1, ARID1A, BRD7)Bromodomain inhibitor drug discoveryEpigenetic gene regulationCancer immunology and DNA damage response

Publication output has fluctuated over the past decade with a peak in 2018 and another surge in 2023, averaging just under 7 papers per year over the last five years without a clear sustained upward or downward trend.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 6.8/year recently
2017: 4 publications172018: 14 publications14182019: 6 publications192020: 3 publications202021: 7 publications212022: 6 publications222023: 12 publications232024: 8 publications242025: 3 publications252026: 5 publications26
Recent publications
Publishes in
  • bioRxiv (Cold Spring Harbor Laboratory)×8
  • Journal of Biological Chemistry×6
  • ChemRxiv×4
  • The FASEB Journal×4
  • ACS Chemical Biology×2
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

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