Chang‐Deng Hu
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
Publications
131
Citations
3,873
Est. group size
~9
Recurring co-author estimate
Active years
31
Publishing since 1995
Chang-Deng Hu's research focuses on prostate cancer biology, particularly how cancer cells change identity (neuroendocrine differentiation) to resist treatment and spread. A major focus is the enzyme PRMT5, which modifies proteins and appears to regulate cancer progression, chemotherapy resistance, and gene expression in prostate and other cancers (including lung cancer and osteosarcoma). The lab also studies related mechanisms like androgen receptor signaling, cell communication via extracellular vesicles, and radiation-induced changes in tumor cells.
Publication output was moderate and fairly steady from 2017-2022, then spiked sharply in 2023 before dropping back down in 2024-2025, suggesting a possible cluster of related outputs rather than a smooth long-term growth trend.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- 642PPathogenicity validation of DMD pseudoexon mutations in patient-derived human induced pluripotent stem cells: a case report
Neuromuscular Disorders · 2025
- M2-like macrophage promotes prostate cancer metastasis by horizontal transfer of TXNDC5 mRNA via extracellular vesicles
European Urology · 2024
- Abstract 1725: Role of PRMT5 in neuroendocrine prostate cancer development
Cancer Research · 2024
- <scp>PRMT5</scp> promotes chemotherapy‐induced neuroendocrine differentiation in <scp>NSCLC</scp>
Thoracic Cancer · 2023
- Supplementary Figures 1-5 from Ionizing Radiation Induces Prostate Cancer Neuroendocrine Differentiation through Interplay of CREB and ATF2: Implications for Disease Progression
2023
- Supplementary Figures 1-5 from Ionizing Radiation Induces Prostate Cancer Neuroendocrine Differentiation through Interplay of CREB and ATF2: Implications for Disease Progression
2023
- Data from Ionizing Radiation Induces Prostate Cancer Neuroendocrine Differentiation through Interplay of CREB and ATF2: Implications for Disease Progression
2023
- Data from Ionizing Radiation Induces Prostate Cancer Neuroendocrine Differentiation through Interplay of CREB and ATF2: Implications for Disease Progression
2023
- PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis
Aging · 2020
- Novel discoveries in urology: big data to microbiome - highlights of the society for basic urologic research 2019 annual meeting.
PubMed · 2020
- Cotargeting of Androgen Synthesis and Androgen Receptor Expression as a Novel Treatment for Castration-Resistant Prostate Cancer
2017
- MP84-08 PROTEIN ARGININE METHYLTRANSFERASE 5 IS A NOVEL EPIGENETIC REGULATOR OF ANDROGEN RECEPTOR IN PROSTATE CANCER
The Journal of Urology · 2016
- PMC×3
- Cancer Research×2
- Journal of Medical Virology×2
- Publisher×2
- medRxiv×2
- Xuehong Deng
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Andrew M. Asberry
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Bennett D. Elzey
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Rami A. Alfar
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Dipankor Chatterjee
Biochemistry, Genetics and Molecular Biology · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
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