Caitlin M. O’Connor

Caitlin M. O'Connor's research centers on a protein called PP2A (protein phosphatase 2A), an enzyme complex that removes phosphate groups from other proteins to regulate cell signaling, and how mutations or dysregulation of PP2A contribute to cancers such as neuroblastoma, uterine cancer, and lung cancer. The work spans structural biology, molecular mechanisms of PP2A complex assembly, and the development of small molecules that restore or alter PP2A activity as potential cancer therapies. This research combines biochemistry and molecular biology approaches with translational applications relevant to cancer genetics and drug development.

Publication output was low and steady through 2017-2022 but increased sharply starting in 2023, suggesting a recent surge in productivity, though this jump is largely driven by numerous supplementary figure entries associated with a single 2025-2026 uterine cancer paper rather than distinct primary publications.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026