LabCompass

John J. Turchi

Biochemistry, Genetics and Molecular Biology · Indiana University

OpenAlex ORCID
DNA Repair MechanismsDNA and Nucleic Acid ChemistryCancer therapeutics and mechanismsRNA modifications and cancerPARP inhibition in cancer therapy

Publications

214

Citations

6,156

Est. group size

—

Recurring co-author estimate

Active years

36

Publishing since 1991

Research summary
AI-generated

John J. Turchi studies how cells detect and repair damage to their DNA, focusing on proteins such as Replication Protein A (RPA) and the Ku70/80 DNA-PK complex that sense and respond to DNA breaks. A central aim of the work is to design small-molecule drugs that block these DNA damage response proteins, making cancer cells—especially BRCA1-deficient tumors and EGFR-driven lung cancers—more vulnerable to treatments like PARP inhibitors and targeted therapies.

DNA repair and damage responseReplication Protein A (RPA) biologyKu/DNA-PK inhibitor drug designPARP inhibitors and synthetic lethality in cancerTargeted cancer therapeutics

Publication activity has grown over the decade, with a marked spike in 2023 and a sustained higher output compared with earlier years.

Generated by claude-opus-4-8 from public bibliographic data · Jul 11, 2026

Publication cadence
Publications per year over the last 10 years — averaging 15.4/year recently
2017: 7 publications172018: 4 publications182019: 5 publications192020: 8 publications202021: 5 publications212022: 10 publications222023: 40 publications40232024: 12 publications242025: 8 publications252026: 7 publications26
Recent publications
Publishes in
  • Cancer Research×19
  • bioRxiv (Cold Spring Harbor Laboratory)×7
  • PMC×4
  • Molecular Cancer Therapeutics×4
  • European Journal of Cancer×4

This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 11, 2026.

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