Zhangfei Shen

This researcher studies the molecular structures and mechanisms behind cellular defense and signaling systems, particularly how proteins and protein complexes assemble to fight viruses (bacteriophages), regulate immune responses, and process genetic material like RNA and DNA. Much of the work uses structural biology techniques to understand how these molecular machines are built and switched on, spanning bacterial anti-phage defense systems, human immune signaling complexes, and RNA-guided gene silencing machinery. This research is relevant to students interested in structural biology, molecular mechanisms of immunity, and RNA/DNA-targeting systems with applications in biotechnology and antiviral defense.

Publication output has grown over the last decade, rising from a handful of papers per year around 2017-2021 to a peak of 10 in 2024, indicating an increasingly active and productive research program.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026