LabCompass

Yu‐Chen Yen

Computer Science · Purdue University West Lafayette

OpenAlex ORCID
Mid career · publishing since 2012
Computational Drug Discovery MethodsReceptor Mechanisms and SignalingProtein Structure and DynamicsProtein Kinase Regulation and GTPase SignalingAlzheimer's disease research and treatments

Publications

31

Citations

399

Est. group size

~6

Recurring co-author estimate

Active years

15

Publishing since 2012

Research summary
AI-generated

Yu-Chen Yen's work focuses on structure-based drug design, using knowledge of protein shapes to guide the development of new drug molecules. A notable example is research on selective inhibitors targeting BACE1 and BACE2 proteins, enzymes implicated in Alzheimer's disease and Type II diabetes, aimed at informing potential treatments. The broader research area draws on protein structure, cell signaling receptors, and enzyme regulation relevant to drug discovery.

Structure-based drug designProtein structure and functionCell signaling and receptor biologyEnzyme (kinase/GTPase) regulationAlzheimer's disease and diabetes-related drug targets

Publication output has been fairly steady over the last decade, fluctuating between 1 and 5 papers per year without a clear long-term increase or decrease.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 2.4/year recently
2017: 2 publications172018: 2 publications182019: 5 publications5192020: 1 publication202021: 3 publications212022: 3 publications222023: 4 publications232024: 4 publications24252026: 1 publication26
Recent publications
  • Structure-Based Drug Design of Selective BACE1 and BACE2 Inhibitors for the Treatments of Alzheimer's Disease and Type II Diabetes

    Purdue e-Pubs (Purdue University) · 2017

Publishes in
  • bioRxiv (Cold Spring Harbor Laboratory)×4
  • The FASEB Journal×3
  • Nature Structural & Molecular Biology×2
  • Bioorganic & Medicinal Chemistry Letters×2
  • ChemMedChem×2
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

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