Yongjun Kou
Biochemistry, Genetics and Molecular Biology · The Ohio State University
Publications
22
Citations
460
Est. group size
~8
Recurring co-author estimate
Active years
13
Publishing since 2014
This researcher studies how cancer cells, particularly brain tumors like glioblastoma, rewire their metabolism—especially lipid (fat) and sugar-related pathways—to fuel their growth, and explores ways to block these pathways as potential therapies. Earlier work in the group also examined the structure and function of cell-surface receptors and calcium-binding proteins involved in cell signaling. The research combines molecular biology, biochemistry, and structural biology approaches.
Publication output has been variable but shows a recent increase, rising from occasional single-paper years earlier in the decade to multiple papers per year in 2020-2021 and again in 2024-2025.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity
Cell Reports · 2026
- TMET-15. SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity
Neuro-Oncology · 2025
- Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth
Science Advances · 2025
- Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
Cell Reports Medicine · 2024
- STAT3 activation of SCAP-SREBP-1 signaling upregulates fatty acid synthesis to promote tumor growth
Journal of Biological Chemistry · 2024
- TMET-05. INCREASING GLUTAMINE UPTAKE-LIPOGENESIS AXIS PROMOTES TUMOR RESISTANCE TO LYSOSOME INHIBITION
Neuro-Oncology · 2024
- TMET-10. TARGETING PGM3 TO INHIBIT HEXOSAMINE PRODUCTION IS AN EFFECTIVE APPROACH TO TREAT GLIOBLASTOMA
Neuro-Oncology · 2024
- TMET-03. ONCOGENIC STAT3 PROMOTES TUMOR GROWTH VIA STIMULATION THE SCAP- AND SREBP-1-REGULATED LIPOGENIC PATHWAY
Neuro-Oncology · 2024
- Nanobodies as negative allosteric modulators for human calcium sensing receptor
Biochemical and Biophysical Research Communications · 2023
- Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms
Cell Calcium · 2023
- Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage
Biomedicines · 2022
- Structural insights into the activation of human calcium-sensing receptor
eLife · 2021
- Non-Canonical Interaction between Calmodulin and Calcineurin Contributes to the Differential Regulation of Plant-Derived Calmodulins on Calcineurin
Journal of Chemical Information and Modeling · 2021
- Structural insights into the activation of human calcium-sensing receptor
bioRxiv (Cold Spring Harbor Laboratory) · 2021
- Author response: Structural insights into the activation of human calcium-sensing receptor
2021
- Neuro-Oncology×4
- Nature×2
- Biophysical Journal×2
- Biomedicines×1
- eLife×1
- Deliang Guo
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Feng Geng
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Grant N. Burcham
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Asmaa El-Kenawi
Biochemistry, Genetics and Molecular Biology · Indiana University
- Xiang Cheng
Biochemistry, Genetics and Molecular Biology · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
Claim or correct this profile