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Yizhen Guo

Biochemistry, Genetics and Molecular Biology · The Ohio State University

OpenAlex ORCID
Established · publishing since 1990
Cancer, Hypoxia, and MetabolismTraditional Chinese Medicine AnalysisCancer Immunotherapy and BiomarkersATP Synthase and ATPases ResearchSpectroscopy and Chemometric Analyses

Publications

44

Citations

1,014

Est. group size

~10

Recurring co-author estimate

Active years

37

Publishing since 1990

Research summary
AI-generated

Yizhen Guo's research focuses on cancer cell metabolism, particularly how tumor cells such as non-small cell lung cancer rewire glucose and energy production pathways to survive and resist drugs like osimertinib. The work explores enzymes involved in this metabolic rewiring (such as hexokinase 2, pyruvate dehydrogenase kinase, and lactate dehydrogenase) as potential drug targets, alongside related projects on nanoparticle-based and natural-compound (e.g., ginsenoside) drug delivery systems for cancer therapy. This research would suit students interested in cancer biochemistry, drug resistance mechanisms, and translational pharmacology.

Cancer cell metabolism and drug resistanceMetabolic enzyme inhibitors (PDK, HK2, LDHA) as cancer targetsNanoparticle and liposomal drug delivery systemsNatural product pharmacology (ginsenosides, flavonoids)Non-small cell lung cancer therapeutics

Publication output has grown over the past decade, rising from just a few papers per year in 2017-2021 to a peak of 9 in 2023, though it has tapered off in 2024-2025.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 3.8/year recently
2017: 4 publications172018: 1 publication182019: 1 publication192020: 2 publications202021: 2 publications212022: 6 publications222023: 9 publications9232024: 2 publications242025: 1 publication252026: 1 publication26
Recent publications
Publishes in
  • Theranostics×2
  • Materials Science and Engineering C×2
  • Journal of Molecular Structure×2
  • Nano-Micro Letters×1
  • Clinical Lung Cancer×1
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 19, 2026.

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