Yi Lien
Materials Science · Purdue University West Lafayette
Publications
16
Citations
154
Est. group size
—
Recurring co-author estimate
Active years
44
Publishing since 1982
This researcher studies the structure and function of proteins and enzymes, including DNA-binding and DNA-repair proteins, radical SAM enzymes involved in peptide biosynthesis, and bioactive compounds from carnivorous plants like Nepenthes and Sarracenia that show potential anticancer, antidiabetic, and antimicrobial effects. The work combines structural biology, biochemistry, and bioinformatics approaches to understand protein mechanisms and screen natural extracts for disease-relevant enzyme inhibition. Recent projects also touch on neurodegenerative disease (Parkinson's) and stem-cell-derived neuron differentiation.
Publication output was low and sporadic in the earlier part of the decade but has increased notably in 2024-2025, suggesting growing recent activity.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Proteomics-based receptor-ligand matching enhances differentiation maturity of human-stem-cell-derived neurons
Stem Cell Reports · 2025
- Inhibition of RPA32 and Cytotoxic Effects of the Carnivorous Plant Sarracenia purpurea Root Extract in Non-Small-Cell Lung Cancer Cells
Plants · 2025
- Bioactive Potential of Nepenthes miranda Flower Extracts: Antidiabetic, Anti-Skin Aging, Cytotoxic, and Dihydroorotase-Inhibitory Activities
Plants · 2025
- Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases
ACS Chemical Biology · 2024
- Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson’s disease
Brain · 2024
- Cytotoxicity and Multi-Enzyme Inhibition of Nepenthes miranda Stem Extract on H838 Human Non-Small Cell Lung Cancer Cells and RPA32, Elastase, Tyrosinase, and Hyaluronidase Proteins
Plants · 2024
- Inhibition of SARS-CoV-2 Nsp9 ssDNA-Binding Activity and Cytotoxic Effects on H838, H1975, and A549 Human Non-Small Cell Lung Cancer Cells: Exploring the Potential of Nepenthes miranda Leaf Extract for Pulmonary Disease Treatment
International Journal of Molecular Sciences · 2024
- Correction to “A structural, biochemical, and bioinformatic basis for identifying radical SAM cyclopropyl synthases.”
ACS Chemical Biology · 2024
- Crystal Structure of DNA Replication Protein SsbA Complexed with the Anticancer Drug 5-Fluorouracil
International Journal of Molecular Sciences · 2023
- Identification of a poly-cyclopropylglycine–containing peptide via bioinformatic mapping of radical S-adenosylmethionine enzymes
Journal of Biological Chemistry · 2022
- How a Subfamily of Radical S-Adenosylmethionine Enzymes Became a Mainstay of Ribosomally Synthesized and Post-translationally Modified Peptide Discovery
ACS Bio & Med Chem Au · 2021
- Ligand-Induced Stabilization of the Native Human Superoxide Dismutase 1
ACS Chemical Neuroscience · 2021
- Identification and characterization of dihydropyrimidinase inhibited by plumbagin isolated from Nepenthes miranda extract
Biochimie · 2020
- Pharmacological activities of <i>Nepenthes miranda</i> extracts
The FASEB Journal · 2019
- Characterization of Staphylococcus aureus Primosomal DnaD Protein: Highly Conserved C-Terminal Region Is Crucial for ssDNA and PriA Helicase Binding but Not for DnaA Protein-Binding and Self-Tetramerization
PLoS ONE · 2016
- Plants×3
- ACS Chemical Biology×2
- International Journal of Molecular Sciences×2
- PLoS ONE×1
- Biochimie×1
- Genki Terashi
Materials Science · Purdue University West Lafayette
- Li Zhao
Materials Science · The Ohio State University
- Brendan Sullivan
Materials Science · Purdue University West Lafayette
- Aloke Kumar Bera
Materials Science · Purdue University West Lafayette
- Jian Hu
Materials Science · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
Claim or correct this profile