Yen-Chiao Wang

Medicine · Indiana University

Corneal Surgery and Treatments Corneal surgery and disorders Connexins and lens biology Wnt/β-catenin signaling in development and cancer Ocular Surface and Contact Lens

Publications

Citations

104

Est. group size

—

Recurring co-author estimate

Active years

Publishing since 2015

Research summary

AI-generated

Yen-Chiao Wang studies the biology of the cornea, the clear front surface of the eye, using genetically engineered mouse models. The work focuses on how cell-signaling pathways (such as TGF-beta, Wnt/beta-catenin, and the Shp2 enzyme) control corneal development, wound healing, and diseases like keratoconus and corneal ectasia, where the cornea thins or bulges abnormally.

Corneal development and diseaseTGF-beta signaling in the eyeWnt/beta-catenin signalingGenetically engineered mouse modelsCorneal wound healing

Publication activity was highest around 2017 and has slowed to roughly one or two papers per year in recent years.

Generated by claude-opus-4-8 from public bibliographic data · Jul 11, 2026

Publication cadence

Publications per year over the last 10 years — averaging 0.6/year recently

Recent publications

SMAD4-Dependent Signaling Pathway Involves in the Pathogenesis of TGFBR2-Related CE-like Phenotype
Cells · 2024
β-Catenin gain of function mutant in mouse periocular neural crest-derived mesenchymal cells impairs embryonic eyelid morphogenesis and leads to blepharophimosis syndrome in mice
The Ocular Surface · 2024
Transforming growth factor beta receptor 2 (Tgfbr2) deficiency in keratocytes results in corneal ectasia
The Ocular Surface · 2023
Inducible Slc4a11 knock out in adult mice produces corneal edema through alteration of pump and barrier functions
Investigative Ophthalmology & Visual Science · 2021
Keratocyte-specific ablation of Tgfbr1, Tgfbr2, and Smad4 manifests differentially keratoconus-like phenotype in mice
Investigative Ophthalmology & Visual Science · 2020
TGF beta signaling in stroma is essential for corneal development
Investigative Ophthalmology & Visual Science · 2019
Shp2 protein tyrosine phosphatase affects the interplay between corneal epithelium and nerve fibers
2018
Expression of a stabilized β-catenin mutant in keratocytes retards corneal epithelial stratification
2018
Keratocyte-derived canonical Wnt signaling modulates corneal wound healing
2018
Shp2 regulates the expression of ΔNp63-alpha in corneal basal epithelial cells
2017
Generation and Characterization of a Novel Mouse Line, Keratocan-rtTA (KeraRT), for Corneal Stroma and Tendon Research
Investigative Ophthalmology & Visual Science · 2017
Shp2 protein tyrosine phosphatase affects corneal epithelial stratification and innervation
Investigative Ophthalmology & Visual Science · 2017
Overexpression of TGF-a is detrimental to the corneal epithelial development
2017
Exogenous TGFβ3 promotes mouse corneal stroma development
Investigative Ophthalmology & Visual Science · 2017
The generation and characterization of a novel mouse line, Cdh2- rtTA (Cdh2rt), for genetic manipulation of stem cell niche tissues
Investigative Ophthalmology & Visual Science · 2017

Publishes in

Investigative Ophthalmology & Visual Science×8
The Ocular Surface×2
BIO-PROTOCOL×1
Cells×1

This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 11, 2026.

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