LabCompass

Yang Huo

Biochemistry, Genetics and Molecular Biology · The Ohio State University

OpenAlex
Early career · publishing since 2017
Bioinformatics and Genomic NetworksComputational Drug Discovery MethodsCRISPR and Genetic EngineeringPharmacogenetics and Drug MetabolismCancer-related Molecular Pathways

Publications

14

Citations

103

Est. group size

~4

Recurring co-author estimate

Active years

10

Publishing since 2017

Research summary
AI-generated

Yang Huo's research focuses on identifying genetic vulnerabilities in cancer cells, particularly using CRISPR-Cas9 gene-editing screens to find genes whose loss makes cancer cells more sensitive to chemotherapy drugs (a concept called 'synthetic lethality'). Much of this work centers on triple-negative breast cancer and multiple myeloma, aiming to identify new drug targets to overcome treatment resistance. The group also applies metabolomics (large-scale profiling of small molecules in tissue) in some studies, including non-cancer biological systems.

CRISPR-based genetic screeningCancer drug resistance and synthetic lethalityTriple-negative breast cancer therapeuticsMultiple myeloma immunotherapy and tumor microenvironmentMetabolomics and genomics approaches

Publication output has been irregular over the last decade, with occasional gaps (e.g., 2018, 2023-2024) and a peak in 2022, followed by renewed output in 2025-2026.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 1.4/year recently
2017: 1 publication17182019: 2 publications192020: 3 publications202021: 1 publication212022: 4 publications42223242025: 2 publications252026: 1 publication26
Recent publications
Publishes in
  • Cancers×2
  • Cancer Research×2
  • PMC×2
  • Frontiers in Genetics×1
  • Genes×1
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 19, 2026.

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