Xianshi Liu
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
Publications
13
Citations
122
Est. group size
—
Recurring co-author estimate
Active years
7
Publishing since 2019
Xianshi Liu uses computational methods, particularly molecular dynamics simulations, to study how proteins linked to amyotrophic lateral sclerosis (ALS), such as TDP-43, hnRNPA2, and FUS, misfold and clump together (aggregate) at the atomic level. This work examines how specific disease-associated mutations change protein shape and behavior, including a process called liquid-liquid phase separation, where proteins temporarily cluster into droplet-like structures inside cells, which can go on to form more permanent, disease-related aggregates.
Publication output was minimal or absent before 2022, then increased to a peak in 2023, and has continued at a steady pace of about 2 papers per year through 2024-2025.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Computational Exploration of the Inhibitory Mechanism of mRNA against the Phase Separation of hnRNPA2 Low Complexity Domains
Journal of Chemical Information and Modeling · 2025
- Molecular Dynamics
ACS in focus · 2025
- Elucidating the reversible and irreversible self-assembly mechanisms of low-complexity aromatic-rich kinked peptides and steric zipper peptides
Nanoscale · 2024
- Evaluation of Essential Dynamics and Fixed-Length Coarse Graining for Multidomain Proteins
The Journal of Physical Chemistry B · 2024
- ALS-Linked A315T and A315E Mutations Enhance β-Barrel Formation of the TDP-43<sub>307–319</sub> Hexamer: A REST2 Simulation Study
ACS Chemical Neuroscience · 2023
- Dissecting how ALS-associated D290V mutation enhances pathogenic aggregation of hnRNPA2286–291 peptides: Dynamics and conformational ensembles
International Journal of Biological Macromolecules · 2023
- Dissecting the Effect of ALS Mutation G335D on the Early Aggregation of the TDP-43 Amyloidogenic Core Peptide: Helix-to-β-Sheet Transition and Conformational Shift
Journal of Chemical Information and Modeling · 2023
- Dataset for computational study of the ALS mutation G335D modulating the dimerization of TDP-43 amyloidogenic core peptide
Zenodo (CERN European Organization for Nuclear Research) · 2023
- Dataset for computational study of the ALS mutation G335D modulating the dimerization of TDP-43 amyloidogenic core peptide
Zenodo (CERN European Organization for Nuclear Research) · 2023
- Insights into the Atomistic Mechanisms of Phosphorylation in Disrupting Liquid–Liquid Phase Separation and Aggregation of the FUS Low-Complexity Domain
Journal of Chemical Information and Modeling · 2022
- ALS-associated A315E and A315pT variants exhibit distinct mechanisms in inducing irreversible aggregation of TDP-43 <sub>312–317</sub> peptides
Physical Chemistry Chemical Physics · 2022
- Atomistic Insights into A315E Mutation-Enhanced Pathogenicity of TDP-43 Core Fibrils
ACS Chemical Neuroscience · 2022
- Magnetic and electronic properties of single-crystalline BaCoSO
Physical review. B./Physical review. B · 2019
- Journal of Chemical Information and Modeling×3
- ACS Chemical Neuroscience×2
- Zenodo (CERN European Organization for Nuclear Research)×2
- International Journal of Biological Macromolecules×1
- Physical Chemistry Chemical Physics×1
- Robin P. Wharton
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Guramrit Singh
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Elizabeth Tran
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- René M. Arvola
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Sarath Chandra Janga
Biochemistry, Genetics and Molecular Biology · Indiana University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
Claim or correct this profile