LabCompass

Xiangnan Guan

Medicine · The Ohio State University

Mid career · publishing since 2013Rising activity

Publications

166

Citations

2,387

Est. group size

Recurring co-author estimate

Active years

14

Publishing since 2013

Research summary
AI-generated

Xiangnan Guan studies how tumors interact with their surrounding cellular environment and immune system, particularly in cancers like prostate cancer, multiple myeloma, and urothelial (bladder) cancer. Recent work focuses on how signaling pathways in tumor-supporting cells (such as fibroblasts) and hormone-related pathways affect tumor resistance to immunotherapy drugs like anti-PD-L1 treatments. This research aims to identify new drug targets and better understand why some cancers resist current immune-based treatments.

Cancer immunotherapy resistanceTumor microenvironment biologyProstate cancer and androgen receptor signalingMultiple myeloma therapeutic targetsPD-L1 and immune biomarkers

Publication output has grown substantially over the past decade, rising from near zero in 2017-2019 to a sharp peak in 2023, with continued high output through 2025-2026.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 28.6/year recently
172018: 2 publications182019: 3 publications192020: 8 publications202021: 7 publications212022: 12 publications222023: 63 publications63232024: 13 publications242025: 31 publications252026: 24 publications26
Recent publications
Publishes in
  • Cancer Research×6
  • Nature×5
  • Journal of Clinical Oncology×5
  • bioRxiv (Cold Spring Harbor Laboratory)×4
  • Proceedings of the National Academy of Sciences×3
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 19, 2026.

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