Trevor A. Trombley
Pharmacology, Toxicology and Pharmaceutics · Purdue University West Lafayette
Publications
10
Citations
55
Est. group size
~2
Recurring co-author estimate
Active years
8
Publishing since 2019
Trevor A. Trombley's work focuses on designing and optimizing small-molecule drugs, including compounds that act on brain receptors (such as mGlu1 and neurotransmitter-related targets) and blood-clotting-related receptors (PAR4), with a particular interest in how chemical modifications like fluorine addition affect a drug's metabolic stability (how long it persists in the body before being broken down). This combines medicinal chemistry, computational virtual screening, and pharmacology to improve drug candidates for psychiatric, cognitive, and other conditions.
After a gap with little activity from 2020-2023, publication output increased sharply starting in 2024, suggesting a recent growth phase.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective
Journal of Medicinal Chemistry · 2026
- On the Metabolic Stability of Fluorinated Small Molecules;A Physical Organic Chemistry Perspective
ChemRxiv · 2026
- Further Optimization of the mGlu<sub>1</sub> PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685
ACS Chemical Neuroscience · 2025
- On the Metabolic Stability of Fluorinated Small Molecules;A Physical Organic Chemistry Perspective
ChemRxiv · 2025
- On the Metabolic Stability of Fluorinated Small Molecules;A Physical Organic Chemistry Perspective
ChemRxiv · 2025
- <b>On the Metabolic Stability of Fluorinated Small Molecules:</b>
Figshare · 2025
- <b>On the Metabolic Stability of Fluorinated Small Molecules:</b>
Figshare · 2025
- Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening
ACS Pharmacology & Translational Science · 2024
- Discovery of VU6024578/BI02982816: An mGlu<sub>1</sub> Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models
Journal of Medicinal Chemistry · 2024
- DARK Classics in Chemical Neuroscience: Gamma-Hydroxybutyrate (GHB)
ACS Chemical Neuroscience · 2019
- ChemRxiv×3
- Journal of Medicinal Chemistry×2
- ACS Chemical Neuroscience×2
- Figshare×2
- ACS Pharmacology & Translational Science×1
- Pankaj Bhattarai
Pharmacology, Toxicology and Pharmaceutics · Purdue University West Lafayette
- Jingheng Wang
Pharmacology, Toxicology and Pharmaceutics · The Ohio State University
- Aditi Shendre
Pharmacology, Toxicology and Pharmaceutics · The Ohio State University
- Hao Chen
Pharmacology, Toxicology and Pharmaceutics · Purdue University West Lafayette
- Hyunyoung Jeong
Pharmacology, Toxicology and Pharmaceutics · Purdue University West Lafayette
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
Claim or correct this profile