LabCompass

Randall J. Roper

Medicine · Indiana University

OpenAlex ORCID
Down syndrome and intellectual disability researchGenetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalitiesConnective tissue disorders researchImmunodeficiency and Autoimmune Disorders

Publications

126

Citations

3,363

Est. group size

—

Recurring co-author estimate

Active years

61

Publishing since 1966

Research summary
AI-generated

Randall J. Roper studies Down syndrome, a genetic condition caused by an extra copy of chromosome 21, using mouse models to understand how it affects the body. Much of the work focuses on how the extra genes (especially one called Dyrk1a) impair bone and skeletal development, often examining differences between males and females. The research also explores related topics such as immune dysfunction and potential drug treatments.

Down syndrome mouse modelsSkeletal and bone developmentGene dosage effects (Dyrk1a, chromosome 21)Sex-specific differences in diseaseImmune response and treatment testing

Publication activity has been fairly steady over the past decade, averaging around four to six papers per year with some year-to-year variation.

Generated by claude-opus-4-8 from public bibliographic data · Jul 11, 2026

Publication cadence
Publications per year over the last 10 years — averaging 3.8/year recently
2017: 5 publications172018: 3 publications182019: 5 publications192020: 6 publications202021: 7 publications7212022: 6 publications222023: 2 publications232024: 5 publications242025: 3 publications252026: 3 publications26
Recent publications
Publishes in
  • IUScholarWorks (Indiana University)×5
  • NeuroMolecular Medicine×3
  • Bone×3
  • PMC×3
  • bioRxiv (Cold Spring Harbor Laboratory)×3

This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 11, 2026.

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