Publications
39
Citations
1,209
Est. group size
—
Recurring co-author estimate
Active years
17
Publishing since 2009
Rajalekshmy Shyam studies the biology of the eye at the molecular and cellular level, with a focus on how cells in the cornea (the clear front surface of the eye) stay healthy or become diseased. Much of the work examines a transporter protein called SLC4A11 and how its loss leads to oxidative stress, faulty energy production in mitochondria, and problems with cellular recycling (autophagy) in conditions like corneal endothelial dystrophy. Other research investigates how the retina takes up and processes carotenoid pigments important for vision.
Publication activity has been fairly steady but modest over the last decade, averaging under two papers per year in the most recent five years.
Generated by claude-opus-4-8 from public bibliographic data · Jul 11, 2026
- Autophagy in the eye: from physiology to pathophysiology
Autophagy Reports · 2023
- Editorial: Molecular mechanisms in ocular development and disease
Frontiers in Cell and Developmental Biology · 2023
- The H+ Transporter SLC4A11: Roles in Metabolism, Oxidative Stress and Mitochondrial Uncoupling
Cells · 2022
- Mitochondrial ROS in Slc4a11 KO Corneal Endothelial Cells Lead to ER Stress
Frontiers in Cell and Developmental Biology · 2022
- Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy
Investigative Ophthalmology & Visual Science · 2021
- Bicarbonate activates glycolysis and lactate production in corneal endothelial cells by increased pHi
Experimental Eye Research · 2020
- MitoROS due to loss of <i>Slc4a11</i> in corneal endothelial cells induces ER stress, lysosomal dysfunction and impairs autophagy
bioRxiv (Cold Spring Harbor Laboratory) · 2020
- Inducible Slc4a11 knock out in adult mice produces corneal edema and oxidative stress
2020
- The NH3/H+ Transporter Slc4a11 Facilitates Glutamine-dependent Mitochondrial Function and ROS Prevention by Mitochondrial Uncoupling
2019
- Ammonia sensitive SLC4A11 mitochondrial uncoupling reduces glutamine induced oxidative stress
Redox Biology · 2019
- Biochemical Mechanisms of Macular Carotenoid Synthesis and Uptake
2019
- 3071 Cell Survival in Corneal Endothelial Dystrophies
Journal of Clinical and Translational Science · 2019
- SLC4A11 is a mitochondrial protein in corneal endothelium.
2019
- Autophagy and mitophagy in SLC4a11 KO Corneal Endothelial cells
Investigative Ophthalmology & Visual Science · 2019
- RPE65 has an additional function as the lutein to <i>meso</i> -zeaxanthin isomerase in the vertebrate eye
Proceedings of the National Academy of Sciences · 2017
- Investigative Ophthalmology & Visual Science×12
- bioRxiv (Cold Spring Harbor Laboratory)×4
- Frontiers in Cell and Developmental Biology×2
- Proceedings of the National Academy of Sciences×1
- Redox Biology×1
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 11, 2026.
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