Patrick D. Halley

Biochemistry, Genetics and Molecular Biology · The Ohio State University

Established · publishing since 1990

Advanced biosensing and bioanalysis techniques RNA Interference and Gene Delivery Nanoparticle-Based Drug Delivery Immunotherapy and Immune Responses Biosensors and Analytical Detection

Publications

Citations

457

Est. group size

Recurring co-author estimate

Active years

Publishing since 1990

Research summary

AI-generated

Patrick D. Halley works on DNA origami, a technique that folds DNA strands into precisely shaped nanoscale structures, and applies it to build delivery vehicles for drugs and genetic material such as siRNA. His research includes engineering these DNA nanostructures for targeted cancer drug delivery, as well as developing tools like DNA-based force sensors to study biomolecules and methods to simplify large-scale production of DNA origami.

DNA origami nanostructuresTargeted drug and gene deliveryCancer nanomedicineDNA nanotechnology fabrication methodsBiomolecular force measurement tools

Publication output has been low but has grown somewhat in recent years, rising from sporadic single papers earlier in the decade to a few publications per year around 2022-2024.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence

Publications per year over the last 10 years — averaging 1.6/year recently

Recent publications

In‑Situ ssDNA Isolation from dsDNA Sources as a Streamlined Pathway to DNA Origami Assembly and Testing
bioRxiv (Cold Spring Harbor Laboratory) · 2026
Abstract 7238: Exploring the potential of targeted DNA Nanobot delivery systems for gene delivery
Cancer Research · 2024
Abstract 828: DNA origami nanostructures as a targeted payload delivery system
Cancer Research · 2023
DNA Origami Nanodevices for Therapeutic Delivery Applications
2022
A nanoscale DNA force spectrometer capable of applying tension and compression on biomolecules
Nucleic Acids Research · 2021
Low-cost, simple, and scalable self-assembly of DNA origami nanostructures
Nano Research · 2019
DNA Origami: Daunorubicin‐Loaded DNA Origami Nanostructures Circumvent Drug‐Resistance Mechanisms in a Leukemia Model (Small 3/2016)
Small · 2016
DNA Origami as a Drug Delivery Vehicle for in vitro and in vivo Applications
OhioLink ETD Center (Ohio Library and Information Network) · 2016

Publishes in

Cancer Research×3
Small×2
Nano Research×1
Nucleic Acids Research×1
Blood Advances×1

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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 19, 2026.

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