Natalia Higuita‐Castro
Biochemistry, Genetics and Molecular Biology · The Ohio State University
Publications
67
Citations
1,540
Est. group size
~20
Recurring co-author estimate
Active years
17
Publishing since 2010
Natalia Higuita-Castro's research focuses on engineering extracellular vesicles (tiny cell-derived particles that carry molecules like proteins and RNA) and using nanotechnology-based gene delivery methods to repair or reprogram tissues, with applications ranging from wound healing and nerve injury repair to lung injury, cancer immunotherapy, and spinal disc disease. Her lab develops tools such as tissue nanotransfection (a technique that reprograms skin cells in place using tiny needle arrays) and lab-on-a-chip devices to study and treat disease. This work sits at the intersection of biomedical engineering, regenerative medicine, and molecular biology, aiming to translate cell and gene therapies into practical clinical tools.
Publication output rose steadily from 2017 to a peak in 2020, then leveled off to a moderate, fluctuating pace of roughly 4-6 papers per year through 2024, with a gap in 2025 and new entries appearing for 2026.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Isolation of Extracellular Vesicles From Mouse Brown Adipose Tissue Secretome Using Size‐Exclusion Chromatography
The FASEB Journal · 2026
- Repurposing the skin to heal the body: Tissue Nanotransfection (TNT) as a therapeutic platform
Med-X · 2026
- Vasculogenic tissue nanotransfection accelerates functional recovery after peripheral nerve injury
Science Advances · 2026
- Engineered extracellular vesicle-based gene therapy for the treatment of discogenic back pain
Biomaterials · 2024
- A micro-scale humanized ventilator-on-a-chip to examine the injurious effects of mechanical ventilation
Lab on a Chip · 2024
- Tissue nano-transfection of antimicrobial genes drives bacterial biofilm killing in wounds and is potentially mediated by extracellular vesicles
Journal of Controlled Release · 2024
- A Micro-scale Humanized Ventilator-on-a-Chip to Examine the Injurious Effects of Mechanical Ventilation
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- A Protocol for co-Injecting Cells with Pulverized Fibers for Improved Cell Survival and Engraftment
BIO-PROTOCOL · 2024
- Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury
Advanced Materials · 2023
- Engineered Extracellular Vesicle-Based Therapies for Valvular Heart Disease
Cellular and Molecular Bioengineering · 2023
- Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype
JOR Spine · 2023
- Engineered Extracellular Vesicles from Human Skin Cells Induce Pro‐<i>β</i>‐Cell Conversions in Pancreatic Ductal Cells
Advanced NanoBiomed Research · 2023
- Injectable pulverized electrospun poly(lactic‐co‐glycolic acid) fibers improve human adipose tissue engraftment and volume retention
Journal of Biomedical Materials Research Part A · 2023
- ICAM-1-decorated extracellular vesicles loaded with miR-146a and <i>Glut1</i> drive immunomodulation and hinder tumor progression in a murine model of breast cancer
Biomaterials Science · 2023
- Nanotechnology-Driven Cell-Based Therapies in Regenerative Medicine
The AAPS Journal · 2022
- The FASEB Journal×3
- Advanced Healthcare Materials×3
- Science Advances×2
- Journal of Biomedical Materials Research Part A×2
- Scientific Reports×2
- María A. Rincon‐Benavides
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Junfeng Shi
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Kwang Joo Kwak
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Eduardo Reátegui
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Colin L. Hisey
Biochemistry, Genetics and Molecular Biology · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
Claim or correct this profile