Marthandan Mahalingam
Environmental Science · Purdue University West Lafayette
Publications
40
Citations
1,141
Est. group size
~1
Recurring co-author estimate
Active years
22
Publishing since 2004
This researcher studies bacteriophage T4, a virus that infects bacteria, and engineers it as a tool for delivering genes, proteins, and vaccine components into human cells and for use as a vaccine platform. Work spans the structural biology of how the virus assembles and packages its DNA, as well as applied uses such as reversing HIV-1 latency and developing dual vaccines against anthrax and plague. The research combines structural (e.g., cryo-EM based) analysis of viral machinery with engineering approaches to repurpose viral particles as delivery vehicles.
Publication output has fluctuated over the last decade, with peaks around 2018-2019 and again in 2024, rather than showing a steady or clearly growing trend.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models
iScience · 2025
- Design of bacteriophage T4-based artificial viral vectors for human genome remodeling
Nature Communications · 2023
- Structures of a large prolate virus capsid in unexpanded and expanded states generate insights into the icosahedral virus assembly
Proceedings of the National Academy of Sciences · 2022
- A viral genome packaging ring-ATPase is a flexibly coordinated pentamer
Nature Communications · 2021
- Targeted Bacteriophage T4 Nanoparticles Reverse HIV-1 Latency in CD4+ Human T Cells
bioRxiv (Cold Spring Harbor Laboratory) · 2021
- A viral genome packaging ring-ATPase is a flexibly coordinated pentamer
bioRxiv (Cold Spring Harbor Laboratory) · 2021
- Structural morphing in a symmetry-mismatched viral vertex
Nature Communications · 2020
- Preparation of a Bacteriophage T4-based Prokaryotic-eukaryotic Hybrid Viral Vector for Delivery of Large Cargos of Genes and Proteins into Human Cells
BIO-PROTOCOL · 2020
- Molecular anatomy of the receptor binding module of a bacteriophage long tail fiber
PLoS Pathogens · 2019
- A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells
Science Advances · 2019
- Formation of gp37 LTF needle trimers-LPS complex v1
2019
- Binding of gp37 LTF needle trimers to E. coli v1
2019
- Formation of gp37 LTF needle trimers-OmpC complex v1
2019
- Bacteriophage T4 nanoparticles for vaccine delivery against infectious diseases
Advanced Drug Delivery Reviews · 2018
- A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague
mBio · 2018
- Nature Communications×5
- eLife×4
- bioRxiv (Cold Spring Harbor Laboratory)×3
- Biophysical Journal×2
- Advanced Drug Delivery Reviews×1
- Andrei Fokine
Environmental Science · Purdue University West Lafayette
- Nikolai S. Prokhorov
Environmental Science · Indiana University
- Marc C. Morais
Environmental Science · Indiana University
- Trevor Douglas
Environmental Science · Indiana University
- Chen Wang
Environmental Science · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
Claim or correct this profile