Mark E. Hester
Biochemistry, Genetics and Molecular Biology · The Ohio State University
Publications
54
Citations
2,911
Est. group size
~10
Recurring co-author estimate
Active years
22
Publishing since 2004
Mark E. Hester's research focuses on using stem-cell-derived models—such as brain organoids (lab-grown, simplified 3D tissue models) and patient-derived cells—to study neurological and genetic diseases including Alzheimer's disease, glioblastoma brain cancer, tuberous sclerosis, and cystic fibrosis. His work combines gene-editing tools like CRISPR-Cas9 with organoid and stem cell platforms to model disease mechanisms and test genetic correction strategies. Recent projects also explore spatial gene expression mapping in brain tissue and lipid regulation pathways linked to neurodegeneration.
Publication output has grown substantially over the last decade, rising from about 1-2 papers per year in 2017-2019 to a steadier pace of 5-7 papers per year from 2021-2024.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Nature Communications · 2025
- Patient-derived organoids recapitulate glioma-intrinsic immune program and progenitor populations of glioblastoma
PNAS Nexus · 2024
- Single-stranded DNA with internal base modifications mediates highly efficient knock-in in primary cells using CRISPR-Cas9
Nucleic Acids Research · 2024
- CRISPR-Cas9-Mediated Correction of <i>TSC2</i> Pathogenic Variants in iPSCs from Patients with Tuberous Sclerosis Complex Type 2
The CRISPR Journal · 2024
- Single-Stranded DNA with Internal Base Modifications Mediates Highly Efficient Gene Insertion in Primary Cells
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- 273 Internal chemical modifications in ssDNA templates enable improved CFTR gene correction and primary airway cell modeling compared to end-modified ssDNA templates
Journal of Cystic Fibrosis · 2024
- Interferome perturbation of human brain organoids induces progenitor and neuronal dysfunction seen in multiple sclerosis and autism (P2-3.015)
Neurology · 2023
- Additional file 10 of Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Figshare · 2023
- Additional file 7 of Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Figshare · 2023
- AUTS2 Syndrome: Molecular Mechanisms and Model Systems
Frontiers in Molecular Neuroscience · 2022
- Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Acta Neuropathologica Communications · 2022
- Intrauterine drug exposure as a risk factor for cerebral palsy
Developmental Medicine & Child Neurology · 2021
- Generation of Neurosphere‐Derived Organoid‐Like‐Aggregates (NEDAS) from Neural Stem Cells
Current Protocols · 2021
- Spatially resolved transcriptomics reveals unique gene signatures associated with human temporal cortical architecture and Alzheimer’s pathology
bioRxiv (Cold Spring Harbor Laboratory) · 2021
- Patient-Derived Organoids Recapitulate Intrinsic Immune Landscapes and Progenitor Populations of Glioblastoma
bioRxiv (Cold Spring Harbor Laboratory) · 2021
- bioRxiv (Cold Spring Harbor Laboratory)×4
- Cell Reports×2
- Brain×2
- Figshare×2
- Stem Cell Reports×1
- Wei Li
Biochemistry, Genetics and Molecular Biology · Indiana University
- Xiaoping Bao
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Qi Zhou
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Ji‐Dong Fu
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Ryan Hicks
Biochemistry, Genetics and Molecular Biology · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
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