Maria C. Sterrett

Biochemistry, Genetics and Molecular Biology · Indiana University

RNA Research and Splicing RNA modifications and cancer RNA and protein synthesis mechanisms Neurobiology and Insect Physiology Research RNA regulation and disease

Publications

Citations

236

Est. group size

—

Recurring co-author estimate

Active years

Publishing since 2017

Research summary

AI-generated

Maria C. Sterrett studies the RNA exosome, a cellular machine that processes and degrades RNA molecules, and how mutations in its components cause human genetic diseases such as pontocerebellar hypoplasia (a disorder affecting brain development). The research uses model organisms like budding yeast, fruit flies, and worms to understand how specific disease-linked mutations disrupt normal RNA and protein production. This work connects basic molecular biology to inherited developmental and neurological conditions.

RNA exosome function and diseaseModeling human genetic mutations in yeast and fliesPost-transcriptional regulation of gene expressionRNA processing and degradationNeurodevelopmental disease mechanisms

Publication activity peaked around 2019-2020 and has continued at a steadier, lower pace of roughly two papers per year since.

Generated by claude-opus-4-8 from public bibliographic data · Jul 11, 2026

Publication cadence

Publications per year over the last 10 years — averaging 1.6/year recently

Recent publications

Comparative analyses of disease-linked missense mutations in the RNA exosome modeled in budding yeast reveal distinct functional consequences in translation
RNA · 2025
Abstract 2429 Disease-associated variants of the structural subunits of RNA exosome complex cause distinct translation defects
Journal of Biological Chemistry · 2024
Comparative analyses of disease-linked missense mutations in the RNA exosome modeled in budding yeast reveal distinct functional consequences in translation
bioRxiv (Cold Spring Harbor Laboratory) · 2023
In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 in Saccharomyces cerevisiae
G3 Genes Genomes Genetics · 2023
In vivo Characterization of the Critical Interaction between the RNA Exosome and the Essential RNA Helicase Mtr4 in Saccharomyces cerevisiae
bioRxiv (Cold Spring Harbor Laboratory) · 2022
Hox proteins interact to pattern neuronal subtypes in Caenorhabditis elegans males
Genetics · 2022
A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex
RNA · 2021
A Budding Yeast Model for Human Disease Mutations in the EXOSC2 Cap Subunit of the RNA Exosome
bioRxiv (Cold Spring Harbor Laboratory) · 2020
The RNA Exosome and Genetic Disease
The FASEB Journal · 2020
Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness
bioRxiv (Cold Spring Harbor Laboratory) · 2020
A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons
PLoS Genetics · 2020
Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness
Human Molecular Genetics · 2020
Functional Analysis of RNA Exosome Mutants Linked to Disease Using a Saccharomyces cerevisiae Model System
The FASEB Journal · 2019
Post‐Transcriptional Regulation of Gene Expression and Human Genetic Disease
Encyclopedia of Life Sciences · 2019
A Drosophila Model of Pontocerebellar Hypoplasia Reveals a Critical Role for the RNA Exosome in Neurons
bioRxiv (Cold Spring Harbor Laboratory) · 2019

Publishes in

bioRxiv (Cold Spring Harbor Laboratory)×7
RNA×2
The FASEB Journal×2
Proceedings of the National Academy of Sciences×1
Development×1

This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 11, 2026.

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