Lijie Gu

Lijie Gu's research focuses on how the liver and metabolism are regulated at the molecular level, particularly involving bile acids (compounds made by the liver that help digest fats and also act as signaling molecules) and a protein degradation system called cullin-RING ligases. This work aims to understand and potentially treat conditions like cholestasis (impaired bile flow), fatty liver disease, insulin resistance, and obesity. An earlier line of work also examined microRNAs (small regulatory RNA molecules) in muscle biology, including muscle wasting and regeneration.

Publication output has been generally steady to slightly increasing over the last decade, with a shift from muscle biology topics (2017-2019) toward liver and metabolic disease research (2021-2025), and an average of about 3-4 papers per year in the last five years.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026