LabCompass

Leifu Chang

Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette

OpenAlex ORCID
Mid career · publishing since 2013
CRISPR and Genetic EngineeringMicrotubule and mitosis dynamicsRNA and protein synthesis mechanismsUbiquitin and proteasome pathwaysPhotosynthetic Processes and Mechanisms

Publications

57

Citations

2,596

Est. group size

~6

Recurring co-author estimate

Active years

14

Publishing since 2013

Research summary
AI-generated

Leifu Chang's lab uses cryo-electron microscopy (a technique for determining detailed 3D structures of large biological molecules) to study how CRISPR-Cas systems and related proteins recognize and act on DNA and RNA. Recent work focuses on CRISPR-Cas12 variants, CRISPR-associated transposons (mobile DNA elements guided by CRISPR machinery), and cell-cycle regulatory protein complexes like the APC/C, revealing how these molecular machines are structured and how they function.

CRISPR-Cas structural biologyCryo-EM structural determinationRNA-guided DNA targeting and transpositionCell cycle and protein complex regulationProtein-RNA/DNA interaction mechanisms

Publication output rose to a peak around 2020-2021, dipped in 2022-2023, and has picked up again through 2025-2026, suggesting a fluctuating but sustained level of activity over the past decade.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 3.2/year recently
2017: 4 publications172018: 2 publications182019: 5 publications192020: 8 publications202021: 10 publications10212022: 2 publications222023: 3 publications232024: 3 publications242025: 5 publications252026: 3 publications26
Recent publications
Publishes in
  • Nature×7
  • bioRxiv (Cold Spring Harbor Laboratory)×5
  • Nature Structural & Molecular Biology×3
  • Nature Communications×3
  • Nucleic Acids Research×2
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By research-topic overlap
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  • Anthony A. Stephenson

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  • Christian S. Wright

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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

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