Kevin R. Coombes
Biochemistry, Genetics and Molecular Biology · The Ohio State University
Publications
690
Citations
19,811
Est. group size
~3
Recurring co-author estimate
Active years
45
Publishing since 1982
Kevin R. Coombes works on computational and statistical methods for analyzing large-scale cancer genomics data, including gene expression, mutation, and single-cell datasets. His work develops software tools and statistical frameworks for tasks like clustering tumors, benchmarking bioinformatics algorithms, analyzing drug response and drug combination effects, and studying biological pathway networks. Much of the research combines methods from statistics, machine learning, and topology to make sense of complex, high-dimensional biological data, often in the context of cancers such as leukemia and digestive tract tumors.
Publication output has grown substantially in recent years, with a large spike in 2023 and continued high activity in 2025, following more modest and variable output earlier in the decade.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- Widespread data leakage inflates accuracy and corrupts biomarker discovery in cancer drug response prediction
bioRxiv (Cold Spring Harbor Laboratory) · 2026
- Clustering Digestive Tract Tumors Using Transcriptomic and Mutation Data
Cancers · 2026
- A shape-constrained regression and wild bootstrap framework for reproducible drug synergy testing
bioRxiv (Cold Spring Harbor Laboratory) · 2026
- Supplementary Excel Files for "Clustering Digestive Tract Tumors Using Transcriptomic and Mutation Data"
Zenodo (CERN European Organization for Nuclear Research) · 2026
- Supplementary Excel Files for "Clustering Digestive Tract Tumors Using Transcriptomic and Mutation Data"
Zenodo (CERN European Organization for Nuclear Research) · 2026
- WayFindR: Investigating Feedback in Biological Pathways
bioRxiv (Cold Spring Harbor Laboratory) · 2026
- WayFindR: investigating feedback in biological pathways
NAR Genomics and Bioinformatics · 2026
- scDIG: An R Shiny Application for Interactive Density-Based Gating of Single-Cell Proteomic and Transcriptomic Data
bioRxiv (Cold Spring Harbor Laboratory) · 2026
- Tissue-aware elastic net decomposition reveals shared and lineage-specific drug response biomarkers
bioRxiv (Cold Spring Harbor Laboratory) · 2026
- Context-dependent correlations mislead transcriptomic network inference in bulk and single-cell data
bioRxiv (Cold Spring Harbor Laboratory) · 2026
- From Pairwise Distances to Neighborhood Preservation: Benchmarking Dimensionality Reduction Algorithms for CyTOF, scRNA-seq, and CITE-seq
bioRxiv (Cold Spring Harbor Laboratory) · 2025
- Benchmarking Long-read Sequencing Tools for Chromosome End-specific Telomere Analysis
bioRxiv (Cold Spring Harbor Laboratory) · 2025
- Transcriptome Complexity Disentangled: A Regulatory Molecules Approach
International Journal of Molecular Sciences · 2025
- SVAlignR: Recovering Structure of Long Molecules from Structural Variation Data
2025
- SillyPutty: Improved clustering by optimizing the silhouette width
PLoS ONE · 2024
- bioRxiv (Cold Spring Harbor Laboratory)×24
- Figshare×9
- Blood×6
- Bioinformatics×6
- Journal of Thoracic Oncology×5
- Kellie J. Archer
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Elnaz Pashaei
Biochemistry, Genetics and Molecular Biology · Indiana University
- Maciej Pietrzak
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Juexin Wang
Biochemistry, Genetics and Molecular Biology · Indiana University
- Qianfan Wu
Biochemistry, Genetics and Molecular Biology · Indiana University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
Claim or correct this profile