Jonah Z. Vilseck
Biochemistry, Genetics and Molecular Biology · Indiana University
Publications
70
Citations
1,985
Est. group size
~1
Recurring co-author estimate
Active years
20
Publishing since 2007
Jonah Z. Vilseck develops computer-based methods to predict how molecules such as drugs, proteins, RNA, and DNA bind to and interact with each other. A central tool in this work is a simulation technique called "\u03bb-dynamics," which allows many chemical variations to be tested efficiently on a computer. Applications include designing drugs that overcome viral resistance and understanding how genetic variants change protein behavior in disease.
Publication activity has grown over the last decade, rising notably in the most recent years (14 in 2025) with a five-year average of about 7.8 per year.
Generated by claude-opus-4-8 from public bibliographic data · Jul 9, 2026
Current awards run through June 2027 — about under a year of funding on record from today. Awards are often renewed, so this is what is currently public, not a forecast.
Tackling Multifaceted Drug Design Problems with Lambda Dynamics Based Technologies
Matched to public NIH RePORTER and NSF records by name and institution. Awards from other agencies are not shown, and a match is not always found — this list may be incomplete.
Typically publishes in teams of ~5 · 13% small-team papers (≤3 authors) · across 21 venues
- Defined by Shape: Elucidating the Molecular Recognition of Dynamic Loops with Covalent Ligands
ChemRxiv · 2026
- Input files for MD and LD simulations of EXOSC3 S1 Domain Variants
Zenodo (CERN European Organization for Nuclear Research) · 2026
- An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicity
Journal of Biological Chemistry · 2026
- Accelerated Combinatorial Drug Design for Human Immunodeficiency Virus Resistance through Seeded Multisite λ-Dynamics
Journal of Chemical Theory and Computation · 2026
- Input files for MD and LD simulations of EXOSC3 S1 Domain Variants
Zenodo (CERN European Organization for Nuclear Research) · 2026
- Quantifying the Structural and Energetic Consequences of EXOSC3 S1 Domain Variants from a Comparative Assessment of λ-Dynamics with Two Charge-Changing Perturbation Strategies
bioRxiv (Cold Spring Harbor Laboratory) · 2025
- Multiple Molecule λ-Dynamics: Probing Drug Resistance with Concurrent Protein and Ligand Perturbations
ChemRxiv · 2025
- Abstract 2126 Accurate in silico predictions of modified RNA interactions to binding proteins with λ-dynamics
Journal of Biological Chemistry · 2025
- Raw data and data accompanying publication: https://doi.org/10.1261/rna.080367.124
Zenodo (CERN European Organization for Nuclear Research) · 2025
- Accurate in silico predictions of modified RNA interactions to a prototypical RNA-binding protein with λ-dynamics
RNA · 2025
- The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling
Redox Biology · 2025
- The Absence of Peroxiredoxin-1 in Human Pancreatic Ductal Adenocarcinoma (Pdac) Markedly Reduces Cell Survival and Tumor Growth When Coupled with the Inhibition of Ref-1 Redox Signaling
SSRN Electronic Journal · 2025
- Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease 1
Protein Science · 2025
- Multisite λ-Dynamics for Protein–DNA Binding Affinity Prediction
Journal of Chemical Theory and Computation · 2025
- Multiple Molecule λ-Dynamics: Probing Drug Resistance with Concurrent Protein and Ligand Perturbations
The Journal of Physical Chemistry Letters · 2025
- Journal of Chemical Theory and Computation×10
- bioRxiv (Cold Spring Harbor Laboratory)×8
- ChemRxiv×6
- The Journal of Physical Chemistry B×5
- Journal of Biological Chemistry×4
- Arghya Chakravorty
Biochemistry, Genetics and Molecular Biology · University of Michigan
- Ryan L. Hayes
Biochemistry, Genetics and Molecular Biology · University of Michigan
- Charles L. Brooks
Biochemistry, Genetics and Molecular Biology · University of Michigan
- Carol Beth Post
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
- Jacob Verburgt
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Sep 1, 2026.
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