LabCompass

Jared C. Lewis

Chemistry · Indiana University

OpenAlex ORCID
Established · publishing since 1967
Catalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCrystallization and Solubility StudiesX-ray Diffraction in CrystallographyEnzyme Catalysis and Immobilization

Publications

239

Citations

10,056

Est. group size

—

Recurring co-author estimate

Active years

60

Publishing since 1967

Research summary
AI-generated

Jared C. Lewis works at the interface of chemistry and biology, engineering enzymes (biological catalysts) to perform useful chemical reactions that they do not normally carry out in nature. A major focus is designing 'artificial metalloenzymes'—proteins fitted with metal-based components—and re-engineering natural enzymes such as halogenases, methyltransferases, and kinases to achieve selective transformations, including reactions that produce a single mirror-image form of a molecule (enantioselective catalysis).

Enzyme engineering for non-native reactionsArtificial metalloenzymes and photocatalysisFlavin-dependent halogenasesEnantioselective (asymmetric) biocatalysisReaction mechanism studies

Publication activity has been variable across the decade, with high output around 2021-2022 and lower counts in the most recent years, averaging about 13 papers per year over the last five years.

Generated by claude-opus-4-8 from public bibliographic data · Jul 9, 2026

Funding
Public award records

Current awards run through June 2029 — about 3 years of funding on record from today. Awards are often renewed, so this is what is currently public, not a forecast.

  • ActiveNIH T32GM131994through Jun 2029 · $321k awarded

    Graduate Training Program in Quantitative and Chemical Biology at Indiana University Bloomington

  • ActiveNSF 2554906through Jun 2029 · $600k awarded

    Generative AI Design and Directed Evolution of Enantioselective Artificial Metalloenzyme Photocatalysts

  • ActiveNIH R35GM152068through Nov 2028 · $502k awarded

    Engineering Halogenases for Small Molecule Functionalization and Enantioselective Catalysis

  • ActiveNSF 2427996through Mar 2028 · $494k awarded

    NSF-DBT: Structural and Biophysical Analysis of Evolved Fe(II)/2-Ketoglutarate-Dependent Azidases to Understand and Expand the Substrate Scope of Enzymatic C-H Functionalization

  • ActiveNSF 2226475through Oct 2026 · $565k awarded

    Collaborative Research: MFB: Integrating Deep Learning and High-throughput Experimentation to Rapidly Navigate Protein Fitness Landscapes for Non-native Enzyme Catalysis

2 earlier awards
  • NSF 2154726Jun 2022 – May 2025 · $497k awarded

    Understanding and Controlling the Selectivity of Visible Light Photocatalysis in Metal Polypyridyl Artificial Metalloenzymes

  • NIH R01GM115665Aug 2015 – Jun 2024 · $317k awarded

    Directed Evolution of Halogenases for Small Molecule Functionalization

Matched to public NIH RePORTER and NSF records by name and institution. Awards from other agencies are not shown, and a match is not always found — this list may be incomplete.

In context
Among 193 established Chemistry PIs within our index
Citations: 10,056cohort median 2,518
h-index: 46cohort median 26
Publications / year (recent): 13.8cohort median 3.4

Typically publishes in teams of ~5 · 19% small-team papers (≤3 authors) · across 29 venues

Publication cadence
Publications per year over the last 10 years — averaging 13.8/year recently
2017: 24 publications172018: 8 publications182019: 23 publications192020: 14 publications202021: 30 publications30212022: 29 publications222023: 14 publications232024: 6 publications242025: 11 publications252026: 9 publications26
Collaborators per year
Distinct co-authors at Indiana University each year — a rough indication of whether the group around this researcher has been growing or contracting. An estimate from co-authorship, not a roster: collaborators are not necessarily lab members, and recent years can be under-counted while indexing catches up.
2017: 0 collaborators at the same institution2018: 0 collaborators at the same institution2019: 0 collaborators at the same institution2020: 0 collaborators at the same institution2021: 11 collaborators at the same institution2022: 7 collaborators at the same institution2023: 0 collaborators at the same institution2024: 0 collaborators at the same institution2025: 6 collaborators at the same institution1719212325
Recent publications
Publishes in
  • ChemRxiv×49
  • The Cambridge Structural Database×37
  • ACS Catalysis×8
  • Angewandte Chemie International Edition×8
  • Angewandte Chemie×8
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Sep 1, 2026.

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