James E. Klaunig
Biochemistry, Genetics and Molecular Biology · Indiana University
Publications
340
Citations
17,718
Est. group size
—
Recurring co-author estimate
Active years
52
Publishing since 1975
James E. Klaunig studies how chemicals cause cancer and liver damage, with a focus on understanding the biological mechanisms (called "modes of action") by which substances like industrial pollutants, pesticides, and PFAS compounds trigger tumors. Much of the work applies this mechanistic understanding to risk assessment—determining whether findings in laboratory animals are relevant to human health. The research also covers liver injury pathways, including roles of small regulatory molecules (microRNAs) and oxidative stress.
Publication activity has been fairly steady over the past decade, ranging from roughly 5 to 11 papers per year with no clear upward or downward trend, averaging about 5.6 per year over the last five years.
Generated by claude-opus-4-8 from public bibliographic data · Jul 11, 2026
- Conflicts of interest in the International Agency for Research on Cancer process of identifying carcinogenic hazards to humans
Human & Experimental Toxicology · 2025
- ToxPoint: Chemical risks and children’s health—building on progress based on science, not panic
Toxicological Sciences · 2025
- Mechanism-Focused Research: The Foundation of Scientifically Based Carcinogen Risk Assessment
Toxicology Letters · 2025
- Expert panel evaluation of the tumor modes of action for 1,4-dioxane and their implications for human risk assessment
Regulatory Toxicology and Pharmacology · 2025
- Evaluating the mode of action of perfluorooctanoic acid-induced liver tumors in male Sprague-Dawley rats using a toxicogenomic approach
Journal of Environmental Science and Health Part C · 2024
- Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury
Communications Biology · 2024
- Mode of action of dieldrin-induced liver tumors: application to human risk assessment
Critical Reviews in Toxicology · 2024
- Assessment of the mode of action of perchloroethylene-induced mouse liver tumors
Toxicology and Industrial Health · 2024
- Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness
Journal of Cellular and Molecular Medicine · 2023
- miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury
Hepatology Communications · 2023
- Evaluation of the carcinogenicity of carbon tetrachloride
Journal of Toxicology and Environmental Health Part B · 2023
- Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans
Toxicological Sciences · 2023
- Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
Archives of Toxicology · 2023
- US regulations to curb alleged cancer causes are ineffectual and compromised by scientific, constitutional and ethical violations
Archives of Toxicology · 2023
- Quantitative Integration of Mode of Action Information in Dose–Response Modeling and POD Estimation for Nonmutagenic Carcinogens: A Case Study of TCDD
Environmental Health Perspectives · 2023
- Regulatory Toxicology and Pharmacology×7
- Archives of Toxicology×6
- Toxicology×5
- The FASEB Journal×5
- Toxicological Sciences×4
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 11, 2026.
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