Jade M. Katinas

Biochemistry, Genetics and Molecular Biology · Indiana University

Cancer, Hypoxia, and Metabolism Cancer, Lipids, and Metabolism Biochemical and Molecular Research DNA Repair Mechanisms Folate and B Vitamins Research

Publications

Citations

131

Est. group size

—

Recurring co-author estimate

Active years

Publishing since 2016

Research summary

AI-generated

Jade M. Katinas conducts research in biochemistry and molecular biology focused on designing drug-like molecules that target cancer cell metabolism, particularly the enzymes involved in one-carbon (folate) metabolism in both the cytosol and mitochondria. The work combines structural biology techniques—such as X-ray crystallography and nuclear magnetic resonance (NMR)-based screening—with medicinal chemistry to develop and characterize potential anti-tumor and anti-infective compounds.

Folate (one-carbon) metabolism and antifolate drugsCancer metabolism and anti-tumor agentsStructure-based drug designNMR fragment screening of protein complexesAnti-infective compounds (e.g., Leishmania)

Publication activity has grown notably over the past decade, with output rising from occasional papers to a peak in recent years and a five-year average of about 11 publications per year.

Generated by claude-opus-4-8 from public bibliographic data · Jul 11, 2026

Publication cadence

Publications per year over the last 10 years — averaging 10.6/year recently

Recent publications

NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex
ACS Medicinal Chemistry Letters · 2025
<scp>Nuclear Magnetic Resonance</scp> ‐based fragment screen of the <scp>E3</scp> ligase Fem‐1 homolog B
Protein Science · 2025
Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates
Molecular Pharmacology · 2024
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria
Journal of Medicinal Chemistry · 2023
Abstract 4902: Mitochondrial and cytosolic folylpolyglutamate synthetase in one-carbon metabolism and anti-tumor efficacy of mitochondrial-targeted antifolates
Cancer Research · 2023
Structural characterization of naphthalene sulfonamides and a sulfonate ester and their in vitro efficacy against Leishmania tarentolae promastigotes
New Journal of Chemistry · 2021
CCDC 1917628: Experimental Crystal Structure Determination
The Cambridge Structural Database · 2021
CCDC 1917626: Experimental Crystal Structure Determination
The Cambridge Structural Database · 2021
CCDC 1917627: Experimental Crystal Structure Determination
The Cambridge Structural Database · 2021
Abstract 4794: Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine analogs
Experimental and Molecular Therapeutics · 2019
Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates
Cancer Research · 2019
Abstract 811: Multi-targeted inhibitors of mitochondrial one-carbon metabolism and cytosolicde novopurine synthesis enzymes as anti-tumor agents
Molecular and Cellular Biology / Genetics · 2019
Sulfonamides as Inhibitors of Leishmania – Potential New Treatments for Leishmaniasis
Anti-Infective Agents · 2017
Inhibitory Effects of Unique Sulfonamides on Leishmania tarentolae and Potential Pathway of Inhibition
2016

Publishes in

Cancer Research×5
Molecular Cancer Therapeutics×3
The Cambridge Structural Database×3
Experimental and Molecular Therapeutics×2
Molecular Pharmacology×1

This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 11, 2026.

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