J.D. Londino

This researcher studies how lung and immune cells use a protein-tagging system called ubiquitination to control infections, especially influenza virus, and inflammation in airway tissue. Much of the work focuses on E3 ubiquitin ligases (enzymes like MARCH10, FBXO24, FBXO45, and STUB1) that mark other proteins for degradation, affecting things like ciliary function, interferon signaling, and cell stress responses in lung epithelial cells. The lab combines cell biology, proteomics, and virology approaches to understand how these regulatory pathways influence lung disease and host defense.

Publication output has grown over the past decade, rising from about 2-5 papers per year in 2017-2019 to a peak of 12 in 2023, with continued activity of 5-7 papers per year in 2024-2025.

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